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Books > Academic & Education > Professional & Technical > Biomedical Science

Textbook of Nephro-Endocrinology (Hardcover): Ajay K Singh, Gordon H. Williams Textbook of Nephro-Endocrinology (Hardcover)
Ajay K Singh, Gordon H. Williams
R3,706 Discovery Miles 37 060 Special order

The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers both researchers and clinicians expert, gold-standard analysis of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoprosis, and, hypoparathyroidism.
* Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems.
* Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work.
* Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field.

Fertilization (Hardcover): Daniel M. Hardy, D. L. Garbers Fertilization (Hardcover)
Daniel M. Hardy, D. L. Garbers
R2,555 R2,423 Discovery Miles 24 230 Save R132 (5%) Special order

Fertilization provides in-depth reviews of individual research topics, while emphasizing key concepts and the significance of findings within other fields. The author identifies essential questions to be answered by future research. Fertilization broadly covers the many molecular and cellular events of animal fertilization and includes a section on unique problems and potential applications of fertilization research.
Key Features
* Provides in-depth reviews of individual research topics
* Emphasizes key concepts and significance of findings to other fields
* Broadly covers the many molecular and cellular events of animal fertilization
* Includes a section on unique problems and potential applications of fertilization research
* Identifies essential questions to be answered by future research

Thyroid Neoplasms, Volume 4 (Hardcover): Boris Draznin Thyroid Neoplasms, Volume 4 (Hardcover)
Boris Draznin; Edited by (ghost editors) Bryan Haugen
R2,131 Discovery Miles 21 310 Special order

This is a unique book on thyroid neoplasms in that it covers many current topics in the area including tumor development, tumor markers and preclinical treatment for advanced cancer as well as practical approaches (radioiodine, ultrasound, thyroglobulin monitoring and PET scanning). This book will give the general reader and specialist a good foundation for what is currently going on in the area of thyroid neoplasms.
*A translational approach to thyriod neoplasms
*Contributions from national experts in research and clinical medicine
*Current and practical approaches to patients with thyroid neoplasms

Obesity - A Ticking Time Bomb for Reproductive Health (Hardcover): Tahir Mahmood, Sabaratnam Arulkumaran Obesity - A Ticking Time Bomb for Reproductive Health (Hardcover)
Tahir Mahmood, Sabaratnam Arulkumaran
R2,043 Discovery Miles 20 430 Special order

Obesity is a continuing issue around the world and in many contexts. The growing number of obese people is an increasing concern for those in the medical profession, and obesity can pose specific challenges in relation to fertility and pregnancy. Patients who are obese require specific considerations and knowledge. Bringing together experts from a variety of specialties to examine the issues and challenges of obesity, this book discusses how obesity affects fertility, reproduction, and pregnancy. Beginning with an exploration of the epidemiology of obesity, further chapters focus on specific issues related to obesity and both male and female reproduction, the complications of obesity during pregnancy and labour, and the long term effects of obesity. This is the most comprehensive resource to examine the topic of obesity and reproductive issues, making it invaluable for medical students, professionals, and researchers in public policy and medicine.
Comprehensive examination of fertility issues arising from male and female obesityClinical knowledge and expertise given to the subjectsIn-depth examination through 47 chapters of a growing, but often overlooked, issue in fertility and pregnancy

Mechanisms of Cardiovascular Aging, Volume 11 - Mechanisms of Cardiovascular Aging Mechanisms of Cardiovascular Aging: v.11... Mechanisms of Cardiovascular Aging, Volume 11 - Mechanisms of Cardiovascular Aging Mechanisms of Cardiovascular Aging: v.11 (Hardcover, New)
Tory Hagen
R2,924 Discovery Miles 29 240 Special order

This volume of "Advances in Cell Aging and Gerontology" provides a timely review on the molecular and cellular basis of cardiovascular diseases (CVD). Age itself is the leading risk factor for cardiovascular diseases, which include loss of vasomotor function, athero- and arterio-sclerosis, hypertension, congestive heart failure and stroke. Together these pathologies comprise the leading causes of permanent disability, hospitalization and death for individuals over the age of 65. Thus, there is a critical need to assess both the age-associated causes leading to CVD as well as the current state of knowledge on preventive regimens designed to slow or modulate disease progression.


This book concisely summarizes the current knowledge related to the major aspects contributing to cardiovascular disfunction in the elderly as well as potential ways of maintaining or improving human cardiovascular healthspan.

Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome (Hardcover): Nair Sreejayan, Debasis Bagchi Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome (Hardcover)
Nair Sreejayan, Debasis Bagchi
R2,855 Discovery Miles 28 550 Special order

Diabetes mellitus affects approximately 20 million people in the US, or nearly 7% of the population. It is expected to increase by 70% within the next 25 years, and numerous epidemiologic studies have demonstrated that type 2 diabetes increases the risk of cardiovascular morbidity and mortality. It is estimated to cost over $92 billion in health care costs and lost productivity. The increased risk is due to the detrimental vascular effects of prolonged exposure to a hyperglycemic, oxidant-rich environment yielding associated cardiovascular risk factors: atherosclerosis, hypertension and clotting abnormalities. Hypertension and dyslipidemia in diabetic patients produces substantial decreases in cardiovascular and microvascular diseases.

"Nutritionaland Therapeutic Interventionsfor Diabetes and Metabolic Syndrome" provides an overview of the current epidemic, outlines the consequences of this crisis and lays out strategies to forestall and prevent diabetes, obesity and other intricate issues of metabolic syndrome. The contributing experts from around the world give this book relevant and up-to-date global approaches to the critical consequences of metabolic syndrome and make it an important reference for those working with the treatment, evaluation or public health planning for the effects of metabolic syndrome and diabetes.
Scientific discussion of the epidemiology and pathophysiology of the relationship between diabetes and metabolic syndromeIncludes coverage of Pre-diabetes conditions plus both Type I and Type II DiabetesPresents both prevention and treatment options"

Advances in Space Biology and Medicine, Volume 4 (Hardcover): S.L. Bonting Advances in Space Biology and Medicine, Volume 4 (Hardcover)
S.L. Bonting
R2,656 Discovery Miles 26 560 Special order

This fourth volume in the series, dedicated entirely to the results of the first European study of the effects of long-term confinement and isolation. The volume continues to attempt to fulfill the aim of this series, to bring the findings and accomplishments in the field of space biology and medicine to a wider group of scientists than merely the relatively small group of biologists and physiologists currently involved in space experimentation.
The contributions are not only nicely spread geographically with three chapters from the United States, two each from Russia, Europe, and Japan, they also offer a wide range of topics in the field, covering humans, animals, plants, cells, and even potential extraterrestrial beings.
As before, not only problems investigated and results obtained are reviewed, but also some of the technical aspects peculiar to this field are treated. An example in this volume is the chapter on virtual environments by Ellis, which is meant to help investigators understand the opportunities that these techniques might offer for future investigations.
In view of the limitations on flight opportunities and the constraints still inherent in orbital experimentation, it is also important to consider the information that can be obtained from studies on the ground. In addition to simulation studies like bed rest for human subjects (see the chapter by Edgerton et al. on neuromuscular adaptation), tail suspension of rats, and plants on a clinostat (see the chapter by Masuda et al.), there is the interesting possibility of using gravitropic mutants for studying the effects of weightlessness on plant growth as described by Takahashi and Suge.
Two chapters are devoted to a review of the results on rats flown on nine Cosmos biosatellite flights between 1973 and 1989: the chapter by Krasnow deals with the neuromorphological effects of micro- and hypergravity; that by Popova and Grigoriev with the metabolic effects of spaceflight. The effects of weightlessness on heart and lung function in humans are reviewed in detail by Bonde-Petersen and Linnarson.
While the study of humans, animals, and plants in spaceflight have taught us much about the effects of the space environment on living organisms, we still have a very limited understanding of the mechanisms operating in these effects. The chapter by Rijken et al. on the effects of gravity on the cellular response to epidermal growth factor demonstrates how, by a judicious use of experiments on the ground and in sounding rockets, the mechanism of a microgravity effect on cell growth could be unravelled.
The question whether there is intelligent life elsewhere in the universe has intrigued mankind for a long time. In the chapter by Coulter et al. on NASA's High Resolution Microwave Survey the project to search for the existence of such life is described. The postscript to this chapter tells how through an unfortunate decision of the U.S. Congress this project after a successful start is threatened with an untimely ending.

Cell Chemistry and Physiology: Part II, Volume 4B (Hardcover): Edward Bittar, Neville Bittar Cell Chemistry and Physiology: Part II, Volume 4B (Hardcover)
Edward Bittar, Neville Bittar
R1,936 Discovery Miles 19 360 Special order

This volume illustrates the extent to which the traditional distinction between biochemical and physiological processes is being obliterated by molecular biology. It can hardly be doubted that the revolution in cell and molecular biology is leading to core knowledge that provides an outline of the integrative and reductionist approach. We view this as the beginning of a new era, that of the integration of learning.
As in the preceding volumes, the choice of topics has been deliberate not only because of the need to keep the volume within reasonable bounds but also because of the need to avoid information over-load. Several relevant topics are dealt with in other modules; for example, the role of G proteins in transmembrane signalling is covered in the Membranes and Cell Signalling module (i.e., Volume 7). Omissions are of course inevitable but they are minor. A case in point is the subject of phosphatases, the treatment of which does not take into account calcineurin. One of the key functions of this Ca2+ -activated protein phosphatase that is also regulated by calmodulin is to desphosphorylate voltage-dependent Ca2+ channels. The mere recognition of such omissions before or after consulting textbooks and journals should be a spur to a more complete discussion by the student of the subject in a small group teaching setting.

Elsevier's Dictionary of Medicine - Spanish-English and English-Spanish<br>About 28,000 terms (Hardcover, New): Simon A.... Elsevier's Dictionary of Medicine - Spanish-English and English-Spanish<br>About 28,000 terms (Hardcover, New)
Simon A. Hidalgo
R4,540 Discovery Miles 45 400 Special order

This is a comprehensive medical and scientific dictionary for the 21st century. New vocabulary is constantly being introduced into fast moving medico-scientific disciplines such as genomics, clinical trials, medico-legal, health economics and pharmacovigilance. This new terminology is included in this dictionary, clearly defined and accurately translated into Spanish.


The dictionary contains more than 28,000 main entries and many subentries: (a) medical terms used outside the medical community, including colloquial usage; (b) technical medical terms in current use in clinical practice and research; (c) new technical terms in the fields of medicine, medical research and basic scientific research applied to medicine, defined in recent years.


The breadth of subjects covered and the accessibility of the definitions make it user-friendly for the educated general public, while the level of detail and state-of-the-art coverage of recent terminology make it a unique tool for professionals.

Caloric Restriction: A Key to Understanding and Modulating Aging, Volume 1 (Hardcover, 1st ed): E. J. Masoro Caloric Restriction: A Key to Understanding and Modulating Aging, Volume 1 (Hardcover, 1st ed)
E. J. Masoro
R2,208 Discovery Miles 22 080 Special order

For many years, it has been known that when rats and mice are given a reduced amount of food, their life span is increased and they remain healthy and vigorous at advanced ages.

What is the reason for this change in the usual pattern of aging? The evidence is overwhelming that the life extension results from a slowing of aging processes. And the factor responsible is the decrease in caloric intake. The obvious question: How does this factor work? A good question - and the reason that research on the anti-aging action of caloric restriction is today one of the most studied research areas in biological gerontology. For it is felt that if the biological mechanisms of the anti-aging action of caloric restriction can be uncovered, we would gain an understanding of the basic nature of aging processes, which would, in turn, yield possible interventions in human aging. This book aims to provide the growing number of researchers in this field (faculty, postdoctoral trainees, and graduate students) with a detailed knowledge of what is known about caloric restriction within the frame of gerontology, as well as insights on future of this field.

Physiology of the Gastrointestinal Tract, Two Volume Set (Hardcover, 5th edition): Hamid M. Said Physiology of the Gastrointestinal Tract, Two Volume Set (Hardcover, 5th edition)
Hamid M. Said
R9,669 Discovery Miles 96 690 Special order

The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn s disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants. "Physiology of the Gastrointestinal Tract, 5/e" covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine.

The new edition is a highly referenced and useful resource for gastroenterologists, physiologists, internists, professional researchers, and instructors teaching courses for clinical and research students.
Discusses the multiple processes governing gastrointestinal functionEach section edited by preeminent scientist in the fieldUpdated, four-color illustrations"

Complementary and Alternative Therapies and the Aging Population - An Evidence-Based Approach (Hardcover, New): Ronald Ross... Complementary and Alternative Therapies and the Aging Population - An Evidence-Based Approach (Hardcover, New)
Ronald Ross Watson
R1,391 Discovery Miles 13 910 Special order

The major objective of this book is to review in detail health problems occurring with significant frequency in aging adults which are proposed to be treated or ameliorated using nutriceuticals as foods and dietary supplements as well as other complementary and alternative therapies. Chapters primarily focusing on nutrients have been excluded to maintain a focus on complementary and alternative medicine (CAM).
Overview of the Book: The book is divided into three general sections as follows: I. Nutriceuticals and Botanicals in Health Promotion; (A) Specific Nutriceuticals Used in Treating Aged, (B) General Nutraceutical Approaches to Therapy with emphasis on cancer. II. Non-nutritional CAM Therapies. (A) Mind-mediated Therapies, (B) Physically Applied CAM Therapies

I. Non-Nutritional Components in Diet and Supplements, Nutriceuticals and their Role in Health Promotion in the Mature Adult.
Nutrient requirements for optimum health and function of aging physiological systems often are quite distinct from young ones. Nutriceuticals, without nutrients as foods or dietary supplements benefit the aged by both protecting nutrients from oxidative damage as well as through their direct biological activity. Recognition and understanding of the role of CAM nutriceuticals in health of the aged is being intensively researched and tested, especially due to the increases in the elderly in the general population. In developed countries, economic restrictions and physical inactivity during aging can significantly reduce food intakes, contributing to nutritional stresses and needs. Many disease entities and cancers are found with higher frequency in the aged. Cancer, trauma, or infectiousdisease can alter intakes of nutriceutical containing foods and/or requirements for various nutrients. Nutriceuticals, especially those of botanical origins have thousands of biologically active chemicals. Thus specific foods and nutriceutical supplementation may be helpful in treatment of aged adults including cancer patients. Many adults and elderly are using foods and nutriceutical supplements above the recommended daily allowance, which may not always be needed for optimal health. To some extent, treatment of these conditions with diet or nutriceutical supplements is a unique problem in the aged. In summary, increasing numbers of older adults and elderly in the population require detailed study and directed research to understand their health problems, using novel nutriceutical and CAM therapies.
II. Nutriceuticals in Disease and Cancer Therapy in Seniors.
Research continues to show that non-nutritional materials in the diet or as supplements can have important health promotion benefits. Those that are antioxidants act, in part, by protecting antioxidant vitamins. However much needs to be learned about benefits and risks of nutriceuticals which have a variety of biological activities in their own right. Therefore botanical extracts and components will be reviewed for their benefits to seniors.
III. Non-dietary Complementary and Alternative Medicine (CAM) Use and Benefits to the Elderly in Health.
The elderly are frequently using various non-traditional and often unproven CAM therapies, beyond nutritional and nutraceutical supplements. Therefore a variety of physical and psychosocial treatments will be evaluated by experts in CAM research for their benefits/risks andthe extent of scientific testing.
*Identifies the important nutritional requirements of the aging population, and how nutraceuticals and other CAM options affect those
* Addresses the many disease entities and cancers are found with higher frequency in the aged, including cancer, trauma, or infectious disease that can alter intakes of nutraceutical containing foods and/or requirements for various nutrients.
* Explores the nutritional materials botanical extracts and components that can have important health promotion benefits and risks, to ensure safe consumption
* Reviews the frequently used non-traditional and often unproven CAM therapies, beyond nutritional and nutraceutical supplements, including a variety of physical and psychosocial treatments.

Genetics of Bone Biology and Skeletal Disease (Hardcover, New): Rajesh V. Thakker, Michael P. Whyte, John Eisman, Takashi... Genetics of Bone Biology and Skeletal Disease (Hardcover, New)
Rajesh V. Thakker, Michael P. Whyte, John Eisman, Takashi Igarashi
R2,907 Discovery Miles 29 070 Special order

This book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics, and with this in mind, it includes general introductory chapters on genetics and bone biology and more specific disease-orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, functional and molecular pathology, diagnostic, counselling and treatment aspects of each disorder.
Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on a broad range of genetic bone issues, as opposed to searching through thousands of journal articles.

Provides a common language for bone biologists and geneticists to discuss the development of bone cells and genetics and their interactions in the development of disease Researchers in all areas bone biology and genetics will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays

For those clinical researchers who are also MDs, correct diagnosis (and therefore correct treatment) of bone diseases depends on a strong understanding of the molecular basis for the disease.

Heart Development and Regeneration (Hardcover, New): Nadia Rosenthal, Richard P. Harvey Heart Development and Regeneration (Hardcover, New)
Nadia Rosenthal, Richard P. Harvey
R3,434 R3,261 Discovery Miles 32 610 Save R173 (5%) Special order

The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry.

"Heart Development and Regeneration, " written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances.

Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases.

Volume Two includes chapters on transcription factors and transcriptional control circuits in cardiac development and disease; epigenetic modifiers including microRNAs, genome-wide mutagenesis, imaging, and proteomics approaches; and the theory and practice of stem cells and cardiac regeneration.

Authored by world experts in heart development and disease

New research on epigenetic modifiers in cardiac development

Comprehensive coverage of stem cells and prospects for cardiac regeneration

Up-to-date research on transcriptional and proteomic circuits in cardiac disease

Full-color, detailed illustrations

Cell Chemistry and Physiology: Part I, Volume 4 (Hardcover, c1995-<1996): Edward Bittar, Neville Bittar Cell Chemistry and Physiology: Part I, Volume 4 (Hardcover, c1995-<1996)
Edward Bittar, Neville Bittar
R1,941 Discovery Miles 19 410 Special order

This is the first of a 4-volume module that is an introduction to the study of cell chemistry and physiology. It is not intended to be encyclopedic in nature but rather a general survey of the subject with an emphasis on those topics that are central to an understanding of cell biology and those that are certain to become of increasing importance in the teaching of modern medicine.
We have followed what appeared to as to be the logical divisions of the subject beginning with proteins. Allewell and her colleagues stress the point that proteins fold spontaneously to form complex three-dimensional structures and that some of them unfold with the help of proteins called chaperones. Michaelis-Menten kinetics are shown by Nelsestuen to describe the behaviour of enzymes in the test tube. The formalism is particularly useful in the search for agents of therapeutic value, as exemplified by methotrexate. Uptake by mammalian cells of substrates and their metabolic conversions are discussed by van der Vusse and Reneman. However, both Welch and Savageau expound the view that the cell is not simply a bagful of enzymes. The biologist is urged by Savageau to abandon Michaelis-Menten formalism and apply the Power Law. The biologist is also told that the approach to arriving at a theory of metabolic control would have to be one of successive approximations requiring the use of the computer. Information gained from comparative biochemistry is shown by Storey and Brooks to have shed new light on mechanisms of metabolic rate depression and freeze tolerance, and to be applicable to organ transplantation technology. We are reminded that enzyme adaptation is partly the result of the presence of a hydrating shell of vicinal water that stabilises conformation of the enzyme. Vicinal water, according to Drost-Hausen and Singleton, lies adjacent to most solids and protein interfaces. The kinks or breaks observed in the slope of the Arrhenius plot are attributed to structural changes in vicinal water. Regulation of cell volume is shown by Hempling to involve regulation of cell water. It could be that the osmo-receptor or volume detection system is a protein that links the cytoskeleton to specific K and C1 channels. Additionally, it is interesting that aquaporins, which are water channel-forming membrane proteins, are now known to exist in both renal and extra-renal tissues. One of the renal porins is affected by vasopressin.
We then pass on to protein synthesis (Rattan) and other important topics including protein glycosylation (Hounsell), methylation (Clarke), ADP-ribosylation (Pearson) and prenylation (Gelb). Among the four types of lipids attached to membrane proteins are the prenyl groups. Ford and Gross in their chapter on lipobiology drive home the point that there is an accumulation of acyl carnitine and lysophospholipids during myocardial infarction.

Hyaluronan in Cancer Biology (Hardcover): Robert Stern Hyaluronan in Cancer Biology (Hardcover)
Robert Stern
R1,222 Discovery Miles 12 220 Special order

Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal.
The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer.
* Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer
* Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination
* Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance

Systemic Lupus Erythematosus (Hardcover, 5th edition): Robert G. Lahita, George Tsokos, Jill Buyon, Takao Koike Systemic Lupus Erythematosus (Hardcover, 5th edition)
Robert G. Lahita, George Tsokos, Jill Buyon, Takao Koike
R5,381 Discovery Miles 53 810 Special order

Systemic lupus erythematosus (S.L.E.), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission.
Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.
To date, lupus has no known cause or cure. Early detection and treatment is the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, anti-malarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, similar to those used in the treatment of cancer, are also used to suppress the immune system in lupus patients.
A new edition of this established and well regarded reference which combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.

* Highly illustrated and in full color throughout
* Basic science section expanded to allow the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment
* Clinical aspects and new drugs will be covered in great detail providing a useful reference to both experienced clinicians and physicians with an interest in lupus in their clinical practice

Nutritional Oncology (Hardcover, 2nd edition): George L. Blackburn Nutritional Oncology (Hardcover, 2nd edition)
George L. Blackburn; Edited by Vay Liang W. Go, John Milner, David Heber
R4,148 R3,922 Discovery Miles 39 220 Save R226 (5%) Special order

Nutritional oncology is an increasingly active interdisciplinary field where cancer is investigated as both a systemic and local disease originating with the changes in the genome and progressing through a multi-step process which may be influenced at many points in its natural history by nutritional factors that could impact the prevention of cancer, the quality of life of cancer patients, and the risk of cancer recurrence in the rapidly increasing population of cancer survivors.
Since the first edition of this book was published in 1999, the idea that there is a single gene pathway or single drug will provide a cure for cancer has given way to the general view that dietary/environmental factors impact the progression of genetic and cellular changes in common forms of cancer. This broad concept can now be investigated within a basic and clinical research context for specific types of cancer. This book attempts to cover the current available knowledge in this new field of nutritional oncology written by invited experts. This book attempts to provide not only the theoretical and research basis for nutritional oncology, but will offer the medical oncologist and other members of multidisciplinary groups treating cancer patients practical information on nutrition assessment and nutritional regimens, including micronutrient and phytochemical supplementation. The editors hope that this volume will stimulate increased research, education and patient application of the principles of nutritional oncology.
NEW TO THIS EDITION:
* Covers hot new topics of nutrigenomics and nutrigenetics in cancer cell growth
* Includes new chapters on metabolic networks in cancer cell growth, nutrigenetics and nutrigenomics
* Presents substantially revised chapters on breast cancer and nutrition, prostate cancer and nutrition, and colon cancer and nutrition
* Includes new illustrations throughout the text, especially in the breast cancer chapter
* Includes integrated insights into the unanswered questions and clearly defined objectives of research in nutritional oncology
* Offers practical guidelines for clinicians advising malnourished cancer patients and cancer survivors on diet, nutrition, and lifestyle
* Provides information on the role of bioactive substances, dietary supplements, phytochemicals and botanicals in cancer prevention and treatment

Platelets (Hardcover, 3rd edition): Alan D. Michelson Platelets (Hardcover, 3rd edition)
Alan D. Michelson
R4,853 Discovery Miles 48 530 Special order

PLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.
Comprehensive and definitive source of knowledge about platelets for clinicians, pathologists and scientists

Integrates the entire field of platelet biology, pathophysiology, and clinical medicine

Full color reference comprising 64 chapters, 1400 pages, and 16,000 references

Contributions from 126 world leaders in their fields New chapters on topics such as the regulation of platelet life span, platelet microRNAs, GPVI and CLEC-2, monitoring of antiplatelet therapy, novel antiplatelet therapy, and making platelets "ex vivo"

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