Internationally acclaimed for more than 40 years, this Series, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this Series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Pharmacology endures as an essential reference for all naturalproduct chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.
Key Features
* Indispensable reference work written by leading experts in the field
* Provides up-to-date, timely reviews on compounds and classes of great interest
* Covers synthesis, biosynthesis, biology, as well as isolation and structure elucidation
* An essential research tool for anyone working with alkaloids from a chemical or biological perspectiveperspective

The first chapter in this volume, by E.S.H. El-Ashry, represents the second part of a trilogy on nucleosides he began in Volume 67. This chapter deals with diseco-nucleosides, or analogs of nucleosides in which thereare two bond disconnections. Other chapters deal with the importance of cyclic sulfates as intermediates in organic synthesis, methlypyridines and other methylazines as precursors to biand polyheterocycles, and the variety of heterocycles in nucleoside analogs in heteromonocyclic bases.

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

Advances in Inorganic Chemistry presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bioinorganic to solid state. This acclaimed serial features reviews written by experts in the area and is an indispensable reference to advanced researchers. Each volume of Advances in Inorganic Chemistry contains an index, and each chapter is fully referenced.

Volume 11 of this series presents five timely reviews on current research on alkaloids. Chapter 1 by Paul L. Schiff, Jr. is a monumental survey of research that has been carried out over the past decade on the "Thalictrum" alkaloids. Forty-six new alkaloids are described from fifteen species of the genus "Thalictrum," as well as 116 alkaloids of known structure from thirty-six species and subspecies of the genus. The chapter includes discussions of isolation and structure elucidation, analysis, biosynthesis, cell culture, and pharmacology. Also featured are inclusive compilations of botanical sources, alkaloids by alkaloid types, and calculated molecular weights of the "Thalictrum" alkaloids.

Chapter 2 by Giovanni Appendino provides a fascinating treatment of Taxine, a collective name referring to a mixture of diterpenoid alkaloids from the yew tree (genus: "Taxus"). Taxine is responsible for the toxic properties of the yew tree that has been documented in historical and fictional literature, from Julius Caesar to Shakespeare, and from Agatha Christie to T.S. Eliot. The chapter treats the history, isolation techniques, structure elucidation, chemistry, and pharmacology of Taxine.

Chapter 3 by Mary D. Menachery surveys the alkaloids of South American Menispermaceae (moonseed family). Many different structural types are included in this family. The alkaloid-bearing plants are woody-vines, shrubs, or small trees. Several of these species possess potent curare activity. The chemistry as well as pharmacology of these alkaloids is summarized.

Chapter 4 by Russell J. Molyneux, Robert J. Nash, and Naoki Asano treats the chemistry and biological activity of the calystegines and related "nor"tropane alkaloids. These polyhydroxylated bicyclic alkaloids represent another class of compounds that inhibit glycosidases, producing profound effects in biological systems by disrupting the essential cellular function of glycoprotein processing.

Chapter 5, a related chapter by Robert J. Nash, Naoki Asano, and Alison A. Watson, reviews polyhydroxylated alkaloids that inhibit glycosidases. Topics covered include distribution, ecological significance and toxicity, isolation, synthesis, and biosynthesis.

This widely acclaimed serial contains authoritative reviews that address all aspects of organometallic chemistry, a field which has expanded enormously since the publication of Volume 1 in 1964. Almost all branches of chemistry and material science now interface with organometallic chemistry - the study of compounds containing carbon-metal bonds. Organometallic compounds range from species which are so reactive that they only have a transient existence at ambient temperatures to species which are thermally very stable. Organometallics are used extensively in the synthesis of useful compounds on both large and small scales. Industrial processes involving plastics, polymers, electronic materials, and pharmaceuticals all depend on advancesments in organometallic chemistry.
In basic research, Organometallics have contributed inter alia to metal cluster chemistry, surface chemistry, the stablilization of highly reactive species by metal coordination, chiral synthesis, the formulation of multiple bonds between carbon and the other elements and between the elements themselves. This book is an essential reference work for the academic and industrial chemist and will provide up-to-date material at the cutting edge of chemistry research.
*
* Metal organic compounds of calcium, strontium, and barium in chemical vapour deposition.
* 17- and 19-electron organometallic complexes.
* Halocarbonyl complexes of molybdenum and tungsten.
* Substituent effects in metallacene chemistry.

"Advances in Quantum Chemistry" publishes surveys of current developments in the rapidly developing field of quantum chemistry--a field that falls between the historically established areas of mathematics, physics, chemistry, and biology. With invited reviews written by leading international researchers, each presenting new results, this quality serial provides a single vehicle for following progress in this interdisciplinary area.

Established in 1960, Advances in Hetrocyclic Chemistry is the definitive serial in the area-one of great importance to organic chemists, polymer chemists, and many biological scientists.

Praise for the Series:
"The typesetting, arrangement of references, and drafting of structural formulas adhere to the high standards of this series and provide a model for good publishing...The content is, as to be expected, excellent."
--Journal of the American Chemical Society
Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area - one of great importance to organic chemists, polymer chemists, and many biological scientists.

Internationally acclaimed for more than forty years, this Series, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structureelucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this Series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Pharmacology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.
Key Features
* Indispensible reference work written by leading experts in the field
* Provides up-to-date, timely reviews on compounds and classes of great interest
* Covers synthesis, biosynthesis, biology, as well as isolation and structure elucidation
* An essential research tool for anyone working with alkaloids from a chemical or biological perspective

Volume 23 of Advances in Chemical Engineering covers the active field of process synthesis. There are currently three prevelant approaches to complex process synthesis strategies: heuristics-based selection, geometric representation, and optimization methods. This volume addresses a variety of these synthesis strategies for process subsystems, representing only a sample of the state-of-the-art of process synthesis research. The five papers in this volume address quite different process subsystems and application areas but still combine basic concepts related to a systematic approach. All five of the papers develop successful synthesis methods for their respective cutting-edge applications. As a group, the papers serve to highlight many unresolved issues in process synthesis and also provide guidelines for future research.
Key Features
* Considers current approaches to process synthesis problems
* Examines areas of possible future research
* Articles written by leading experts in the field

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Every fifth volume ofAdvances in Heterocyclic Chemistry contains a cumulative subject index.

Since its inception in 1945, this serial has provided critical articles by research specialists in the industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

Volumes 21 and 22 of Advances in Chemical Engineering contain ten prototypical paradigms which integrate ideas and methodologies from artificial intelligence with those from operations research, estimation andcontrol theory, and statistics. Each paradigm has been constructed around an engineering problem, e.g. product design, process design, process operations monitoring, planning, scheduling, or control. Along with the engineering problem, each paradigm advances a specific methodological theme from AI, such as: modeling languages; automation in design; symbolic and quantitative reasoning; inductive and deductive reasoning; searching spaces of discrete solutions; non-monotonic reasoning; analogical learning;empirical learning through neural networks; reasoning in time; and logic in numerical computing. Together the ten paradigms of the two volumes indicate how computers can expand the scope, type, and amount of knowledge that can be articulated and used in solving a broad range of engineering problems.
Key Features
* Sets the foundations for the development of computer-aided tools for solving a number of distinct engineering problems
* Exposes the reader to a variety of AI techniques in automatic modeling, searching, reasoning, and learning
* The product of ten-years experience in integrating AI into process engineering
* Offers expanded and realistic formulations of real-world problems

Volumes 21 and 22 of Advances in Chemical Engineering contain ten prototypical paradigms which integrate ideas and methodologies from artificial intelligence with those from operations research, estimation andcontrol theory, and statistics. Each paradigm has been constructed around an engineering problem, e.g. product design, process design, process operations monitoring, planning, scheduling, or control. Along with the engineering problem, each paradigm advances a specific methodological theme from AI, such as: modeling languages; automation in design; symbolic and quantitative reasoning; inductive and deductive reasoning; searching spaces of discrete solutions; non-monotonic reasoning; analogical learning;empirical learning through neural networks; reasoning in time; and logic in numerical computing. Together the ten paradigms of the two volumes indicate how computers can expand the scope, type, and amount of knowledge that can be articulated and used in solving a broad range of engineering problems.
Key Features
* Sets the foundations for the development of computer-aided tools for solving a number of distinct engineering problems
* Exposes the reader to a variety of AI techniques in automatic modeling, searching, reasoning, and learning
* The product of ten-years experience in integrating AI into process engineering
* Offers expanded and realistic formulations of real-world problems

Advances in Inorganic Chemistry presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry ranging from bio-inorganic to solid state studies. Thisacclaimed serial features reviews written by experts in the area and is an indispensable reference to advanced researchers. Each volume of Advances in Inorganic Chemistry contains an index, and each chapter is fully referenced.

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area-one of great importance to organic chemists, polymer chemists, and many biological scientists. Every fifth volume ofAdvances in Heterocyclic Chemistry contains a cumulative subject index.

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Every fifth volume ofAdvances in Heterocyclic Chemistry contains a cumulative subject index.
Key Features
* A selection of topics covered in Volume 62
* Synthesis possibilities in "N"-Fluoropyridinium salts
* An updated review of Pyran Chemistry
* The organic chemistry and synthesis of Tetrathia- and tetraselena-fulvalenes
* A review of the classes of five-membered heterocyclic rings containing two sulfur and two nitrogen atoms, both as anionic and radical species

This widely acclaimed serial contains authoritative reviews that address all aspects of organometallic chemistry, a field which has expanded enormously since the publication of Volume 1 in 1964. Almost all branchesof chemistry now interface with organometallic chemistry-the study of compounds containing carbon-metal bonds. Organometallic compounds range from species which are so reactive that they only have a transient existence at ambient temperatures to species which are thermally very stable. Organometallics are used extensively in the synthesis of useful compounds on both large and small scales. Industrial processes involving plastics, polymers, electronic materials, and pharmaceuticals all depend on advancements in organometallic chemistry.
Key Features
* In basic research, organometallics have contributed "inter alia" to:
* Metal cluster chemistry
* Surface chemistry
* The stabilization of highly reactive species by metal coordination
* Chiral synthesis
* The formulation of multiple bonds between carbon and the other elements and between the elements themselves

Advances in Chemical Engineering, Volume 19 reflects the major impact of chemical engineering on medical practice, with chapters covering polymer systems for controlled release, receptor binding and signaling, and transport phenomena in tumors. Other key topics include oil refining, pollution prevention in engineering design, and atmospheric dynamics.

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area-one of great importance to organic chemists, polymer chemists, and most biological scientists. Every fifth volume ofAdvances in Heterocyclic Chemistry contains a cumulative subject index.

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area-one of great importance to organic chemists, polymer chemists, and most biological scientists. Volume 60 contains a cumulative subject index covering Volumes 55 through 60.

Since its inception in 1945, this serial has provided critical articles by research specialists in the industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

Advances in Inorganic Chemistry presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry ranging from bio-inorganic to solid state studies. Thisacclaimed serial features reviews written by experts in the area and is an indispensable reference to advanced researchers. Each volume of Advances in Inorganic Chemistry contains an index, and each chapter is fully referenced.

Internationally acclaimed for more than 40 years, this serial, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine origins, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids, Chemistry and Pharmacology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.