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Written by Caleb Finch, one of the leading scientists of our time,
The Biology of Human Longevity - Inflammation, Nutrition, and Aging
in the Evolution of Lifespans synthesizes several decades of top
research on the topic of human aging and longevity particularly on
the recent theories of inflammation and its effects on human
health. The book expands a number of existing major theories,
including the Barker theory of fetal origins of adult disease to
consider the role of inflammation and Harmon's free radical theory
of aging to include inflammatory damage. Future increases in
lifespan are challenged by the obesity epidemic and spreading
global infections which may reverse the gains made in lowering
inflammatory exposure. This timely and topical book will be of
interest to anyone studying aging from any scientific angle.
The Handbook of Statistics, a series of self-contained reference books. Each volume is devoted to a particular topic in statistics. Every chapter is written by prominent workers in the area to which the volume is devoted. The series is addressed to the entire community of statisticians and scientists in various disciplines who use statistical methodology in their work. At the same time, special emphasis is placed on applications-oriented techniques, with the applied statistician in mind as the primary audience.
This volume presents a state of the art exposition of topics in the field of industrial statistics. It serves as an invaluable reference for the researchers in industrial statistics/industrial engineering and an up to date source of information for practicing statisticians/industrial engineers. A variety of topics in the areas of industrial process monitoring, industrial experimentation, industrial modelling and data analysis are covered and are authored by leading researchers or practitioners in the particular specialized topic. Targeting the audiences of researchers in academia as well as practitioners and consultants in industry, the book provides comprehensive accounts of the relevant topics. In addition, whenever applicable ample data analytic illustrations are provided with the help of real world data.
Hardbound. This volume of the Handbook is concerned particularly with the frequency side, or spectrum, approach to time series analysis. This approach involves essential use of sinusoids and bands of (angular) frequency, with Fourier transforms playing an important role. A principal activity is thinking of systems, their inputs, outputs, and behavior in sinusoidal terms. In many cases, the frequency side approach turns out to be simpler with respect to computational, mathematical, and statistical aspects. In the frequency approach, an assumption of stationarity is commonly made. However, the essential roles played by the techniques of complex demodulation and seasonal adjustment show that stationarity is far from being a necessary condition. Assumptions of Gaussianity and linearity are also commonly made and yet, as a variety of the papers illustrate, these assumptions are not necessary. This volume complements Handbook of Statistics 5: Time Series in the
This volume of "Progress in Brain Research "documents recent
developments and research findings in relation to sex and how the
brain s function and behavior differs from men to women. Specific
areas include cerebral function, morphology and organization,
sexual dimorphism, neural origins, and genetics and epigenetics, as
well as potential causes/affects of stress, pain, sexual
orientation and identity and other social issues such as
distribution of disorders across thesexes and autism.
This volume encompasses a variety of topics pertaining to patients with altered levels of consciousness, including valuable differences between disorders. Neurologists, researchers, and clinicians will find a comprehensive accounting of the distinctions between disorders that cause these altered states. Beginning with basic concepts of consciousness and neurobiology, this handbook progresses into more targeted and complex areas of discussion, including important technological advancements that have occurred in neuroimaging.
Neurologists who are frequently called upon for prognostication
and to guide management of patients with these disorders will find
invaluable information, including chapters discussing comatose
states in children and pregnant women, encephalopathic patients,
nutrition disorders, and vegetative and minimally conscious states.
In addition, chapters devoted to philosophical backgrounds and
ethical implications involving patients with impaired
consciousness, are thoroughly presented.
Developmental Neuroscience is one of the six core disciplines in Neuroscience, and yet no single volume, non-textbookreference exists on the market that provides researchers with more in-depth, high-levelinformation on developmental neurobiology. Currently, anyone interested in the field at a higher level must sift through review articles published frequently and the more specific handbooks that focus on aspects of development rather than the field as a whole.
This reference is the first of its kind to fill this need. It
pulls together the relevant articles on the topic from the
10-volume Encyclopedia of Neuroscience (Academic Press, 2008) and
serves as an affordable and immediate resource for scientists,
postdocs, graduate students with an interest beyond the basic
textbook materials on the subject.
The Handbook of Clinical Neurology Vol 100: Hyperkinetic Movement Disorders discusses hyperkinetic disorders related mainly to basal ganglia dysfunction and pathology. It contains 13 sections and 51 chapters written by authoritative and experienced investigators and clinicians in this extremely broad and diverse group of diseases and syndromes. The first section on choreoathetoid diseases and syndromes includes chapters on Huntington's disease and Huntington's disease look-alikes; spinocerebellar degenerations; neuroacanthocytosis; entatorubral-pallidoluysian atrophy; neuroferritinopathy; neurodegeneration with brain iron accumulation; mitochondrial disorders; acquired hepatocerebral degeneration; benign hereditary chorea; and "senile chorea." The remaining chapters focus on the abnormal involuntary movements associated with each disease or syndrome. These include immune-related chorea, vascular chorea, metabolic disturbances that can induce chorea, chorea in other medical settings (e.g., postpump chorea in children, cancer-related paraneoplastic syndromes), myoclonus, essential tremor, and dystonia, including dystonia plus syndromes. There are also chapters on tardive dyskinesia, unusual clinical syndromes, and tics and stereotyped movements in children. The text is a valuable resource for neurology and psychiatry residents, practicing neurologists and psychiatrists, and specialists in movement disorders.
This volume provides a comprehensive exploration of stroke, from basic mechanisms of disease to enhanced diagnostic and therapeutic capabilities. The ongoing efforts within the neurological community are also highlighted, bringing a better understanding of the pathophysiological basis of this disorder.
Clinicians will find invaluable information that can be used to enhance the lives of an aging global population. Covered topics include the functional anatomy of the brain itself, as well as advancements in the understanding of the biochemical background of strokes.
Related fields and their dramatic impact on stroke research are
also included, with findings in the fields of epidemiology,
genetics, neuroimaging, and interventional radiology thoroughly
explored. In addition, great attention is paid to therapeutic
avenues, including investigation, prevention, and patient
Handbook of Clinical Neurology: Neuro-Oncology, Part II provides an overview of the most recent developments in the field of neuro-oncology, including new diagnostic imaging techniques, along with immunology, molecular biology, and clinical aspects of different types of tumors. It also considers management and new therapeutic strategies for tumors, such as gene therapy, radiation therapy, and molecularly targeted treatments. Divided into five sections encompassing 33 chapters, the book begins with a description of specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. It then discusses tumors at special sites, from brainstem tumors to peripheral nerve tumors, tumors of the meninges, and optic, hypothalamic, and thalamic tumors. It also explains the neurological complications of systemic cancer and the adverse effects of some treatments. Clinicians and neuroscientists, as well as researchers who read this book, will gain a better understanding of the clinical features and management of the neurological manifestations of tumors.
Natural product chemistry covers a fascinating area of organic chemistry and its study has enriched organic chemistry in a myriad of different ways. In recent years the thrust has been in three major directions: advances in stereoselective synthesis of bioactive natural products, developments in structure elucidation of complex natural products through the applications of multidimensional NMR and mass spectroscopy, and the integration of bioassay procedures with the isolation processes leading to the isolation of active principles from the extracts. The present volume reflects these developments, and the growing emphasis on bioactive natural products, chemical constituents of echinoderms, diterpenoids from Rabdosia and Eremophila sp., structural studies on saponins, marine sesquiterpene quinones and antimicrobial activity of amphibian venoms. The reviews on bioactive metabolites of Phomophis, cardenolide detection by ELISA, xenocoumacins and bioactive dihydroisocoumarins, CD studies of carbohydrate-molybdate complexes, oncogene function inhibitors from microbial secondary metabolites and Gelsemium and Lupin alkaloids present frontier developments in several areas of natural product chemistry. It is hoped that the present volume, which contains articles by eminent authorities in each field, will be received with the same enthusiasm as the previous volumes of this series.
This book is devoted to the surgical treatment of epilepsy and its consequences, and provides an extraordinary perspective on the fascinating question of the relationship between brain and mind. Contrary to the current emphasis on statistics and objectivity, this book is dedicated to understanding the whole person, the life and experiences of the individual. It reports on cutting-edge technical skills provided with a human touch. This book reflects the understanding that the temporolimbic seizure originates in tissue providing the substrate for the emotional life and memory. Finally, it emphasizes the value of clinical research - here, conducted in the course of the diagnosis and surgical treatment of epilepsy - in helping to elucidate the relationship between brain and mind.
General Description of Series
The purpose of this book is to review the basic science and
clinical findings concerning maternal substance abuse and the
developing nervous system of unborn children. The short-term but
vitally significant repercussions of such exposure on biological
development, with particular reference to the nervous system, are
discussed. The book also discusses the profound influence of
maternal substance abuse on behavior in adulthood, which is caused
by subtle changes in the chemistry or structure of the developing
nervous system. The subject will not only be of interest to
clinical and basic science researchers and teachers in the field of
maternal substance abuse, but also to individuals in psychology,
social work, cellular and molecular biolgoy, embryology,
neuroscience, pharmacology, and in clinical professions such as
pediatrics, neonatology, and obstetrics. The breadth of topics
covered includes alcohol, cocaine, opiates, nicotine,
benzodiazepines, marijuana, and the role of stress and hormones.
Emphasis is placed on the relationship of the effects of substance
abuse on neurotrophic factors and receptors.
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