This fourth volume in the series Methods of Cancer Diagnosis, Therapy and Prognosis discusses various methodologies for the diagnosis, therapy and prognosis of Colorectal Cancer. Both standard and emerging therapies for this cancer, written by expert oncologists/pathologists in this field, are included. This fully illustrated volume * Presents surgical, radiological, and molecular therapies and prognostic markers for colorectal cancer. * Highlights a large number of methods for diagnosing colorectal cancer at various stages of development, including immunohistochemistry, in situ hybridization immunoscintigraphy, RT- PCR, free circulating DNA levels in blood and stool, ultrasonography, CT, PET, and MRI. * Includes imaging technologies for assessing the treatment results, as are details related to colonoscopy and sigmoidoscopy. * Explains the use of anticancer agents and monoclonal antibodies, including 5-fluorouracil, fluoropyrimidines, leucovorin, irinotecan, oxaliplatin, raltitrexed, capecitabine, cetuximab, and bevacizumab. * Compares preoperative chemoradiotherapy with postoperative chemoradiotherpy. The technological advances presented in this volume are expected to expedite new discoveries and their translation to clinical practice. Oncology will benefit the most from these advanced methods, as a combination of therapies and personalized medicine will improve early detection of colorectal cancer and other cancer types. Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editinga must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology.

This book addresses neuroblastoma, a type of embryonic tumor derived from neural crest cells and one of the most frequent extra-cranial solid tumors in children. However, the term also describes a heterogeneous group of tumors, the prognosis of which can differ greatly according to age, stage and biology. Some forms undergo spontaneous regression, and some are cured by surgery alone or after chemo-reduction, while others exhibit extremely aggressive behavior. Their successful treatment is one of the best examples of tailored medicine, which involves close collaboration between pediatric surgeons, pediatric oncologists, radiologists, nuclear medicine specialists, biologists, oncogeneticists and radiotherapists. The book pursues a unique approach, as it combines most essential insights from all of these fields, together with key information regarding epidemiology, physiopathology and palliative care. The respective chapters were written by the leading international experts on neuroblastoma, and present the latest advances in terms of research, surgical approaches and medical treatments. The book offers an invaluable resource to all pediatric surgeons, pediatricians, oncologists, students, researchers and all others involved in neuroblastoma management who want to benefit from their colleagues' expertise.

This book examines the considerations, drawbacks, and advancements minimally invasive techniques have provided in the evaluation, management, and outcomes across a broad range of colorectal disease and procedures. For some readers of this book, a minimally invasive approach to colorectal disease may add a new dimension to the management of these patients. For others, it is the opportunity to learn helpful tips, specifics about a certain procedure, or to fine tune what has already become a routine part of their practice. Even if you have successfully overcome many of the technical challenges of minimally invasive surgery, the preoperative evaluation, perioperative decision-making, and management of postoperative complications can be demanding and consuming. Wherever you may be on this spectrum, Robotic Approaches to Colorectal Surgery is a useful resource to surgeons.

Mit neu entwickelten diagnostischen Moeglichkeiten und verbesserten Therapieverfahren ist eine zunehmend differenzierte Behandlung von Lungenmetastasen boesartiger Tumoren moeglich geworden. Je nach Ursprungstumor und klinischer Situation wird ein unterschiedliches Vorgehen empfohlen. Neben onkologischen Gesichtspunkten ruckt auch die verbleibende Lungenfunktion in den Mittelpunkt des Interesses. Die moderne Bildgebung, offene und minimal invasive Operationsverfahren und interdisziplinare Therapiekonzepte zu den einzelnen Tumorentitaten sind detailliert und praxisorientiert beschrieben.

Novalis (R) Shaped Beam Radiosurgery has set new standards by delivering highly precise radiation treatments to tumors anywhere in the body through the use of a proprietary multileaf collimator. By shaping the radiation beam to the exact contours of the tumor or lesion, Novalis permits maximum dose delivery to the entire tumor while protecting healthy tissue; this makes it eminently suitable for the treatment of irregularly shaped tumors. This book provides a complete guide to radiosurgery treatments with Novalis. After a thorough discussion of the clinical and technical basis for Shaped Beam Radiosurgery, current clinical applications are considered in detail, including brain, body, skull base, and spinal tumors as well as arteriovenous malformations. Careful consideration is also given to future developments and applications, including new technologies that promise to offer even more accurate treatments. This state-of-the-art book will appeal to a wide audience of physicians and their multidisciplinary clinical and technical collaborators.

Esophageal cancer causes an estimated 386,000 deaths worldwide and is the sixth most common cause of death for men. The background characteristics of esophageal cancer treatment are markedly different between Asian and Western countries, however. In tumor histology, squamous cell carcinoma associated with smoking and alcohol consumption is overwhelmingly prevalent in Asia, whereas adenocarcinoma associated with Barrett's metaplasia is markedly prevalent in the West. In Asia, especially in Japan, the key persons who play important roles in the management of esophageal cancer patients are surgeons; in the West those roles are filled by medical and radiation oncologists as well as surgeons. The philosophy of surgeons regarding cancer surgery varies from locoregional to local tumor control, particularly in focusing on lymph node dissection. Physicians' approach to surgical adjuvant therapy differs, therefore, between Asia and the West. Considering these East-West differences in esophageal cancer treatment, the currently available results of Western evidence should not be considered directly applicable to esophageal cancer in Asia. In this book, the authors discuss the knowledge base in Japan in terms of treatment of esophageal squamous cell carcinoma. Since this volume contains a wide spectrum of current information and addresses topics surrounding the treatment of patients with esophageal squamous cell carcinoma, it is highly relevant to Asian physicians and researchers as well as to their counterparts in the West.

This is the second edition of a well-received book reflecting the state of the art in oncologic imaging research and promoting mutual understanding and collaboration between radiologists and clinical oncologists. It presents all currently available imaging modalities and covers a broad spectrum of oncologic diseases for most organ systems. Today, oncologic imaging faces the challenge of improving and refining concepts for precise tumor delineation and biologic/functional tumor characterization, as well as for purposes of creating individual treatment plans. The concept of radiomics has further advanced the conversion of images into mineable data and subsequent analysis of said data for decision-making support. Since the release of the book's first edition, radiomics has been introduced in oncology studies and can be performed with tomographic images from CT, MRI and PET/CT studies. The combination of radiomic data with genomic features is known as radiogenomics, and can potentially offer additional decision-making support. This book will be of interest to clinical oncologists with regard to the diagnosis, staging, treatment and follow-up on various tumors affecting the CNS, chest, abdomen, urogenital and musculoskeletal systems.

This volume of the "IARC Monographs" provides a reassessment of the carcinogenicity of about a dozen aromatic amines and organic dyes. Additionally, occupational exposures of hairdressers and barbers and exposure from personal use of hair colorants were reviewed. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans from exposure to these agents.