Forensic DNA Applications: An Interdisciplinary Perspective was
developed as an outgrowth of a conference held by the International
Society of Applied Biological Sciences. The topic was human genome
based applications in forensic science, anthropology, and
individualized medicine. Assembling the contributions of
contributors from numerous regions around the world, this volume is
designed as both a textbook for forensic molecular biology students
and a reference for practitioners and those in the legal
system.
The book begins with the history and development of DNA typing
and profiling for criminal and civil purposes. It discusses the
statistical interpretation of results with case examples,
mitochondrial DNA testing, Y single nucleotide polymorphisms (SNPs)
and short tandem repeats (STRs), and X SNP and STR testing. It also
explores low copy number DNA typing, mixtures, and quality
assurance and control.
The second section examines the collection and preservation of
biological evidence under a variety of different circumstances and
the identification of human remains including in mass disaster
settings. It discusses applications to bioterrorism investigations,
animal DNA testing in criminal cases, pedigree questions and
wildlife forensic problems, applications in forensic entomology,
and forensic botany.
The third section explores recent developments and new
technologies, including the rigorous identification of tissue of
origin, mtDNA profiling using immobilized probe strips, chips and
next-generation sequencing, the use of SNPs to ascertain phenotypic
characteristics, and the "molecular autopsy" that looks at aspects
of toxicogenetics and pharmacogenetics.
The book concludes with a discussion on law, ethics, and policy.
It examines the use of DNA evidence in the criminal justice system
in both the United States and Europe, ethical issues
in forensic laboratory practices, familial searches, DNA
databases, ancestry searches, physical phenotyping, and report
writing. The contributors also examine DNA applications in
immigration and human trafficking cases and international
perspectives on DNA databases."
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