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Heat Shock Factor (Hardcover, 1st ed. 2016)
Loot Price: R4,440
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Heat Shock Factor (Hardcover, 1st ed. 2016)
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This book presents a large amount of information related to the
heat shock response and heat shock factor (HSF), describes core
observations about molecular mechanisms and pathophysiological
roles, and provides fundamental concepts on the basis of
information from diverse aspects. This adaptive response to high
temperature or protein misfolding is a fundamental mechanism to
maintain the capacity of protein homeostasis, or proteostasis, and
is evolutionally conserved among all living organisms, including
bacteria and humans, on the earth. Furthermore, physiological and
pathological roles of HSF have been extensively studied in fruit
fly, worm, and mouse models. It has been revealed that HSF plays
roles in development of the brain, reproductive and sensory organs,
and in ageing, inflammation, and circadian rhythm. Analysis of the
mechanisms have uncovered that HSF exerts a wide range of effects
on gene expression and epigenetic status on the whole genome.
Moreover, loss or gain of HSF function is also closely related to
protein-misfolding diseases including neurodegenerative diseases,
psychiatric diseases, heart diseases, and cancers. Therefore, HSF
is now thought to be a promising therapeutic target for treatment
of these refractory diseases. For undergraduate students, this is a
highly understandable source of information on heart shock response
and HSF, covering the basis of HSF biology, the physiological role
of HSF, and disease associated with HSF function. This book not
only serves as a guide to the heat shock response and HSF for
students and young researchers in other fields, but also is a
cornerstone for future work in the field related to the heat shock
response and HSF.
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