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The Molecular Immunology of Complex Carbohydrates (Paperback, Softcover reprint of the original 1st ed. 1988)
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The Molecular Immunology of Complex Carbohydrates (Paperback, Softcover reprint of the original 1st ed. 1988)
Series: Advances in Experimental Medicine and Biology, 228
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During the past three decades, the sugar moiety of complex
carbohydrates has been found to be involved in important
interactions of immunological specificity of antigens and to
participate in a variety of cellular functions. The long
polysaccharide side chains of the lipopolysaccharides on the outer
membrane of Gram negative organisms provide surface antigens for
differential serodiagnosis. Bacterial surface lectins are important
in mediating the attachment of bacteria to host cells in the of
infectious diseases. The carbohydrate pathogenesis moieties of cell
surface glycoconjugates (glycoproteins and glycolipids) of mammals
are the sites for intercellular recognition and for the regulatory
molecular interactions such as interaction of complex carbohydrate
with hormones or hepatic lectins. The carbohydrate side chains of
many complex carbohydrates play essential roles as antigenic
determinants b of human blood group ABH, Lea, Le , I, and i
activities, as the Forssman specific determinant, and as tumor
associated antigenic determinants. Prompted by these and other
advances in the field, a Symposium on Molecular Immunology of
Complex Carbohydrates was organized as a satellite meeting of the
8th International Glycoconjugate Conference held on September 8-
13, 1985, in Houston, Texas, U. S . A. Many eminent scientists
contributed their knowledge at this meeting. The lecture and poster
materials of the symposium are contained in this proceeding book,
which is divided into four Sections and one Appendix. Section I is
entitled Antibody Specificity, Epitope, and Lectinology. Dr. Elvin
A.
General
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