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Controlled Release Systems - Advances in Nanobottles and Active Nanoparticles (Hardcover)
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Controlled Release Systems - Advances in Nanobottles and Active Nanoparticles (Hardcover)
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In the area of controlled release of active substances, such as
drugs, a strong interest in nanoparticles as carriers of active
ingredients has arisen. Some of the active components are extremely
hydrophobic, without cellular permeability and susceptible to
metabolic degradation. Owing to this, their use is limited. This
kind of agent can be transported without any problem through
physiological media by using nanoparticles. The size of particles
is an important parameter because it governs the efficiency of the
delivery system. For this type of application, particles that have
a diameter smaller than 1 m are especially useful. Polymeric
nanoparticles that have diameters in the colloidal range are
produced by means of polymerization processes in dispersed media.
Drugs are taken up into the nanoparticles by adsorption,
absorption, or "entrapment," or covalent bonding and they are
delivered (release) by desorption, diffusion, polymer degradation,
or a combination of these mechanisms. Nanoparticles (including
nanogels) that release their contents by external triggering open
up new possibilities for therapeutic strategies. External
triggering by light, heat, change in pH, or application of
ultrasound opens up the possibility to release the material on
demand. If only a part of the wall of the nanoparticle
(nanocapsule) is responsive, we are dealing with the so-called
nanobottles, a nanocontainer with the active substance and a lid on
the container that can be "opened" and "closed" by external
triggering. This book focuses on responsive nanoparticles and
brings together two interesting areas: nanoparticles and responsive
polymers. The concept of the book is that of a systematic approach
from nanoparticles synthesis via responsive polymers to
nanobottles. The second part of the book presents contributions
from experts in the field and provides a state-of-the-art overview
of the field.
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