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Neurotoxic Factors in Parkinson's Disease and Related Disorders (Hardcover, 2000 ed.)
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Neurotoxic Factors in Parkinson's Disease and Related Disorders (Hardcover, 2000 ed.)
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nd This book stems from the 2 Parkinson's Disease Symposium on
"Neurotoxic Factors in Parkinsons disease and related disorders,"
held on August 6-7,1999 at the University ofUlm Medical School in
Ulm at the Danube, Germany. The symposium wasalso asatellite
ofthejointmeetingofthe InternationalSocietyfor Neurochemistry (ISN)
and the European Society for Neurochemistry (ESN) that followed
immediately afterwards in Berlin. The specific topic, neurotoxic
factors in Parkinson's disease (PD), was chosen in light of
accumulating neurobiological and epidemiological evidence
indicating that the causes of this second most common
neurodegenerative disorder, and possibly of related conditions such
as multiple systems atrophy, in some manner involve environ mental
(xenobiotic) and even endogenous toxic agents. This volume brings
together much of that neurobiological evidence; and in
epidemiology, several recent major studies ofPD - for example, a
study of20,000 twins published in the Journal of the American
Medical Association in 1999 - conclude that environmental and life
style than genetics, appear to be critical in the idiopathic
disease. However, factors, rather the precise roles of neurotoxic
factors in the pathogenesis of PD and related basal ganglia
disorders remain uncertain, despite the cascade of research
resulting from the discovery of the prototype MPTP in the early
1980's, and frankly, we have been surprised by the paucity of
concentrated attention on specific environmental agents other than
MPTP."
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