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Advances in Artificial Pancreas Systems - Adaptive and Multivariable Predictive Control (Paperback, 1st ed. 2018)
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Advances in Artificial Pancreas Systems - Adaptive and Multivariable Predictive Control (Paperback, 1st ed. 2018)
Series: SpringerBriefs in Bioengineering
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This brief introduces recursive modeling techniques that take
account of variations in blood glucose concentration within and
between individuals. It describes their use in developing
multivariable models in early-warning systems for hypo- and
hyperglycemia; these models are more accurate than those solely
reliant on glucose and insulin concentrations because they can
accommodate other relevant influences like physical activity,
stress and sleep. Such factors also contribute to the accuracy of
the adaptive control systems present in the artificial pancreas
which is the focus of the brief, as their presence is indicated
before they have an apparent effect on the glucose concentration
and so can be more easily compensated. The adaptive controller is
based on generalized predictive control techniques and also
includes rules for changing controller parameters or structure
based on the values of physiological variables. Simulation studies
and clinical studies are reported to illustrate the performance of
the techniques presented.
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