Books > Medicine > Clinical & internal medicine > Geriatric medicine
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Aging and Health - A Systems Biology Perspective (Hardcover)
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Aging and Health - A Systems Biology Perspective (Hardcover)
Series: Interdisciplinary Topics in Gerontology and Geriatrics, 40
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Aging is a major risk factor for chronic diseases, which in turn
can provide information about the aging of a biological system.
This publication serves as an introduction to systems biology and
its application to biological aging. Key pathways and processes
that impinge on aging are reviewed, and how they contribute to
health and disease during aging is discussed. The evolution of this
situation is analyzed, and the consequences for the study of
genetic effects on aging are presented. Epigenetic programming of
aging, as a continuation of development, creates an interface
between the genome and the environment. New research into the gut
microbiome describes how this interface may operate in practice
with marked consequences for a variety of disorders. This analysis
is bolstered by a view of the aging organism as a whole, with
conclusions about the mechanisms underlying resilience of the
organism to change, and is expanded with a discussion of circadian
rhythms in aging. Finally, the book presents an outlook for the
development of interventions to delay or to reverse the features of
aging. The publication is recommended to students, researchers as
well as professionals dealing with public health and public policy
related to an aging society.
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