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Pharmacy (Paperback)
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Discovery Miles 12 170
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Pharmacy (Paperback)
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Total price: R1,237
Discovery Miles: 12 370
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The aim of the present research work was to investigate the
potential of emulgel in enhancing the topical delivery of
ketoconazole. Emulsion in gel have emerged as one of the most
interesting topical drug delivery system as it has dual release
control system i.e. emulsion and gel. Also the stability of
emulsion is increased when it is incorporated in gel. Emulgel
formulations of Ketoconazole were prepared using 2 types of gelling
agents: Carbopol 934 and Carbopol 940. The influence of the type of
the gelling agent and the concentration of both the oil phase and
emulsifying agent on the drug release from the prepared emulgel was
investigated using a 23 factorial design. The prepared emulgel were
evaluated for their physical appearance, viscosity, drug release,
globule size, skin irritation test, antifungal activity,
transmission electron microscopy, Ex vivo Syudy, In Vivo Study and
stability. Commercially available ketoconazole cream was used for
comparison. All the prepared emulgel showed acceptable physical
properties concerning color, homogeneity, consistency,
spreadability, and pH value. The antifungal activity and drug
release were found to be higher for optimized formulation .
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