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A Clinician's Guide to Sperm DNA and Chromatin Damage (Hardcover, 1st ed. 2018)
Loot Price: R7,302
Discovery Miles 73 020
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A Clinician's Guide to Sperm DNA and Chromatin Damage (Hardcover, 1st ed. 2018)
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This comprehensive, up-to-date text, which brings together the key
practical elements of the rapidly evolving field of sperm DNA and
chromatin abnormalities, is divided thematically into five main
sections. Part I discusses human sperm chromatin structure and
nuclear architecture, while part II presents laboratory evaluation
of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays,
and cytochemical tests. Biological and clinical factors in the
etiology of sperm DNA damage are discussed in part III, including
oxidative stress, abortive apoptosis, cancer, and environmental and
lifestyle factors. Part IV presents clinical studies on the utility
of sperm DNA damage tests, both with natural and ART-assisted
pregnancies, and debates the clinical utility of such tests.
Finally, part V discusses current treatment options, such as
antioxidant therapy, varicocelectomy, advanced sperm processing
techniques and the use of testicular sperm. We are now beginning to
better understand the unique organization of the sperm chromatin,
as well as the nature and etiology of sperm DNA damage. Written and
edited by worldwide experts in andrology, A Clinician's Guide to
Sperm DNA and Chromatin Damage is an excellent resource for
reproductive medicine and REI specialists, urologists, reproductive
biologists and any professional working with the infertile male.
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