Ubiquitous and fundamental in cell mechanics, multiscale
problems can arise in the growth of tumors, embryogenesis, tissue
engineering, and more. Cell Mechanics From Single Scale-Based
Models to Multiscale Modeling brings together new insight and
research on mechanical, mathematical, physical, and biological
approaches for simulating the behavior of cells, specifically tumor
cells.
In the first part of the text, the book discusses the powerful
tool of microrheology for investigating cell mechanical properties,
multiphysics and multiscale approaches for studying intracellular
mechanisms in cell motility, and the role of subcellular effects
involving certain genes for inducing cell motility in cancer.
Focusing on models based on physical, mathematical, and
computational approaches, the second section develops tools for
describing the complex interplay of cell adhesion molecules and the
dynamic evolution of the cell cytoskeleton. The third part explores
cell interactions with the environment, particularly the role of
external mechanical forces and their effects on cell behavior. The
final part presents innovative models of multicellular systems for
developmental biology, cancer, and embryogenesis.
This book collects novel methods to apply to cells and tissues
through a multiscale approach. It presents numerous existing tools
while stimulating the discovery of new approaches that can lead to
more effective and accurate predictions of pathologies.
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