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Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology
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Models of Seizures and Epilepsy (Hardcover, New)
Loot Price: R2,794
Discovery Miles 27 940
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Models of Seizures and Epilepsy (Hardcover, New)
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An understanding of mechanisms underlying seizure disorders depends
critically on the insights provided by model systems. In particular
with the development of cellular, molecular, and genetic
investigative tools, there has been an explosion of basic epilepsy
research. Models of Seizures and Epilepsy brings together, for the
first time in 30 years, an overview of the most widely-used models
of seizures and epilepsy. Chapters cover a broad range of
experimental approaches (from in vitro to whole animal
preparations), a variety of epileptiform phenomenology (including
burst discharges and seizures), and suggestions for model
characterization and validation, such as electrographic,
morphologic, pharmacologic, and behavioral features. Experts in the
field provide not only technical reviews of these models but also
conceptual critiques - commenting on the strengths and limitations
of these models, their relationship to clinical phenomenology, and
their value in developing a better understanding and treatments.
Models of Seizures and Epilepsy is a valuable, practical reference
for investigators who are searching for the most appropriate
laboratory models for addressing key questions in the field. It
also provides an important background for physicians, fellows, and
students, offering insight into the potential for advances in
epilepsy research.
. The first comprehensive description of animal models of epilepsy
since the early 1970's
. Comprehensive analysis of "What the models model" to guide the
selection of each model, and what specific questions it will answer
. Elegant examples of the use of novel technologies that can be
applied in experimental epilepsy research
. World expert opinions on the clinical relevance of each model"
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