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Hit and Lead Profiling (Hardcover)
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Hit and Lead Profiling (Hardcover)
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The only reference on current methods to generate pharmacokinetic
and safety profiles of drug candidates, as well as how they must be
balanced against one other for the best selection of candidates for
further development.
Following a brief introduction to the necessities of filtering and
risk assessment of potential new drug molecules before actual drug
development, the two equally important aspects of pharmacological
(ADME) and safety (toxicity) profiling are covered in separate
parts.
The ADME section covers the profiling of basic physicochemical
parameters, such as solubility and permeability, as well as more
complex traits, such as the likelihood of drug-drug interactions,
metabolic clearance and protein binding properties.
The toxicology part addresses, among others, recent advances in
early genetic toxicity testing, bioactivation screening,
organ-specific toxicity assays for liver, heart, kidney and blood,
as well as profiling for autoimmune reactions.
By addressing both drug efficiency and drug safety, this modern
practical reference shows readers how each individual aspect
figures in shaping the key decisions on which the entire drug
development process hinges. In short, this is a complete toolbox
for assessing the risk/benefit ratio for any novel compound during
the early drug development stages, using both in vitro and in
silico methods.
Both editors are based at one of the leading research-driven
pharmaceutical companies, and the authors have been recruited from
numerous other global players in the field.
Invaluable know-how for every medicinal chemist and drug developer.
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