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Acute Kidney Injury (Hardcover)
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Acute Kidney Injury (Hardcover)
Series: Contributions to Nephrology, 156
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Acute kidney injury is defined as an abrupt change in serum
creatinine and/or urine output, and a majority of patients admitted
to the ICU have some evidence of the disorder. Unfortunately,
treatment for this complex syndrome is as yet lacking and
understanding is limited. An interdisciplinary panel of experts has
contributed to this volume, illuminating some of the fundamental
and complex aspects of the disorder ranging from pathophysiology to
treatment, from emerging biomarkers to genetic polymorphisms. Other
contributions focus on immunological issues or the many
complications of acute kidney injury and co-morbid conditions
encountered, covering the fundamentals as well as the latest
developments. Moreover, important technical aspects of
extracorporeal therapies including vascular access, anticoagulation
or fluid composition are introduced, and different approaches to
renal support from intermittent dialysis to continuous therapies
and hybrid techniques are discussed. A description of advanced
extracorporeal techniques of organ support and their role in the
management of sepsis and acute kidney injury in the context of an
overall strategy of multi-organ failure management concludes the
discussions. This volume not only provides a practical and
up-to-date summary of current knowledge and technology, but also
imparts a fundamental understanding of the pathogenesis and likely
future developments in this field. It also serves to challenge and
re-examine the fundamental underlying assumptions we hold regarding
critical illness in general and acute kidney injury in particular.
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