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Feedback Control in Systems Biology (Hardcover)
Loot Price: R3,194
Discovery Miles 31 940
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Feedback Control in Systems Biology (Hardcover)
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Like engineering systems, biological systems must also operate
effectively in the presence of internal and external
uncertainty-such as genetic mutations or temperature changes, for
example. It is not surprising, then, that evolution has resulted in
the widespread use of feedback, and research in systems biology
over the past decade has shown that feedback control systems are
widely found in biology. As an increasing number of researchers in
the life sciences become interested in control-theoretic ideas such
as feedback, stability, noise and disturbance attenuation, and
robustness, there is a need for a text that explains feedback
control as it applies to biological systems. Written by established
researchers in both control engineering and systems biology,
Feedback Control in Systems Biology explains how feedback control
concepts can be applied to systems biology. Filling the need for a
text on control theory for systems biologists, it provides an
overview of relevant ideas and methods from control engineering and
illustrates their application to the analysis of biological systems
with case studies in cellular and molecular biology. Control Theory
for Systems Biologists The book focuses on the fundamental concepts
used to analyze the effects of feedback in biological control
systems, rather than the control system design methods that form
the core of most control textbooks. In addition, the authors do not
assume that readers are familiar with control theory. They focus on
"control applications" such as metabolic and gene-regulatory
networks rather than aircraft, robots, or engines, and on
mathematical models derived from classical reaction kinetics rather
than classical mechanics. Another significant feature of the book
is that it discusses nonlinear systems, an understanding of which
is crucial for systems biologists because of the highly nonlinear
nature of
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