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Endothelial Progenitor Cells - A New Real Hope? (Hardcover, 1st ed. 2017)
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Endothelial Progenitor Cells - A New Real Hope? (Hardcover, 1st ed. 2017)
Series: UNIPA Springer Series
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This book explores the role of endothelial progenitor cells (EPCs)
in the context of regenerative medicine (RegMed). In particular, it
reveals the value of RegMed as a new TM branch intended to improve
the health and quality of life, by restoring, maintaining or
enhancing tissue and functions of organs. The book is divided into
three chapters, the first of which describes the relevance of
translational medicine (TM) as a new research approach to
counteract the imposing challengeof age-related diseases. Of the
diverse RegMed approaches, particular attention is paid to
stem/progenitor cell-based therapies, their benefits and
shortcomings, as well as to the description of types of stem and
progenitor cells considered for regenerative cell therapies, such
as EPCs as emerging candidates for RegMed applications. In turn,
the second chapter outlines the clinical relevance of EPCs as both
potential predictors, diagnostic and prognostic biomarkers of
age-related diseases and therapeutic agents,discussing their
advantages, disadvantages, and conflicting data. Chapter three
proposes a potential roadmap for revising the findings and creating
a clearer picture of valid data, which can provide support for
various important aspects, i.e.isolating and characterizing EPCs by
establishing standardized criteria for EPC research, identifying
appropriate sub-populations for cell therapy, timing, dosing,
priming of cells,and defining delivery modes for different
applications. The book concludes with an overview of innovative
strategies that could improve the efficacy of cell therapy at all
levels, including cell priming, bio-nanotechnology, and tissue
engineering.
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