Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP) (Hardcover, 1st ed. 2015)

Phosphatases, such as TNAP are fundamental in regulating the roles of cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity. Regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer's disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. This book aims to provide an overview of our current understanding of the functions of TNAP in the brain and on other tissues and organs.

General

Imprint:	Springer
Country of origin:	Netherlands
Series:	Subcellular Biochemistry, 76
Release date:	August 2015
Editors:	Caroline Fonta • Laszlo Negyessy
Dimensions:	235 x 155 x 28mm (L x W x T)
Format:	Hardcover - Cloth over boards
Pages:	395
Edition:	1st ed. 2015
ISBN-13:	978-9401771962
Categories:	Books > Science & Mathematics > Biology, life sciences > Developmental biology Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > General Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > Animal physiology
LSN:	9401771960
Barcode:	9789401771962

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