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Mechanisms of Gene Regulation (Hardcover, 2nd ed. 2016)
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Mechanisms of Gene Regulation (Hardcover, 2nd ed. 2016)
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This textbook aims to describe the fascinating area of eukaryotic
gene regulation for graduate students in all areas of the
biomedical sciences. Gene expression is essential in shaping the
various phenotypes of cells and tissues and as such, regulation of
gene expression is a fundamental aspect of nearly all processes in
physiology, both in healthy and in diseased states. This pivotal
role for the regulation of gene expression makes this textbook
essential reading for students of all the biomedical sciences, in
order to be better prepared for their specialized disciplines. A
complete understanding of transcription factors and the processes
that alter their activity is a major goal of modern life science
research. The availability of the whole human genome sequence (and
that of other eukaryotic genomes) and the consequent development of
next-generation sequencing technologies have significantly changed
nearly all areas of the biological sciences. For example, the
genome-wide location of histone modifications and transcription
factor binding sites, such as provided by the ENCODE consortium,
has greatly improved our understanding of gene regulation.
Therefore, the focus of this book is the description of the
post-genome understanding of gene regulation. The purpose of this
book is to provide, in a condensed form, an overview on the present
understanding of the mechanisms of gene regulation. The authors are
not aiming to compete with comprehensive treatises, but rather
focus on the essentials. Therefore, the authors have favored a high
figure-to-text ratio following the rule stating that "a picture
tells more than thousand words". The content of the book is based
on the lecture course, which is given by Prof. Carlberg since 2001
at the University of Eastern Finland in Kuopio. The book is
subdivided into 4 sections and 13 chapters. Following the
Introduction there are three sections, which take a view on gene
regulation from the perspective of transcription factors, chromatin
and non-coding RNA, respectively. Besides its value as a textbook,
Mechanisms of Gene Regulation will be a useful reference for
individuals working in biomedical laboratories.
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