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Oligodendrogliomas (ODs) - Diagnosis, Outcomes & Prognosis (Hardcover)
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Oligodendrogliomas (ODs) - Diagnosis, Outcomes & Prognosis (Hardcover)
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Cancer is the second leading cause of morbidity and mortality
worldwide, ranking just after cardiovascular diseases. In the
central nervous system, gliomas constitute the most frequent type
of tumors. According to the definition, oligodendrogliomas are
diffusely infiltrating glial tumors, composed of neoplastic
oligodendroglial cells, typically found in cerebral hemispheres in
adult population, although not uncommon in children. They encompass
a range of tumours, from well-differentiated to frankly malignant
neoplasms. In the current World Health Organization (WHO)
classification of tumors of the central nervous system, covering a
four-tiered WHO grading scheme, oligodendrogliomas are recognised
as grade WHO II and WHO III by the degree of malignancy. They may
be either well differentiated, composed of neoplastic cells that
morphologically resemble oligodendroglia, or may harbor focal or
diffuse features of malignancy, respectively. Their prognosis is in
this case less favorable. This book provides current research on
the diagnosis, outcomes and prognosis of oligodendrogliomas.
Chapter one examines the pathology, molecular mechanisms and
clinical references of ODs. Chapter two discusses the ODs and the
problematic diagnostic markers. Chapter three examines the
histopathologic features of oligodendrogliomas and of an assortment
of other central nervous system neoplasms that can resemble them
and reviews features that allow one to sort through these
histopathologic differential diagnoses. The final chapter reviews
speech mapping in oligodendroglioma operations and provides data
regarding patient outcomes with these methods.
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