Type 2 diabetes mellitus has had proponents proposing a genetic
causation, others preferring to consider this adult-onset disease
as having its origins in foetal life. The Maltese island population
in the Central Mediterranean is an excellent population, because of
its rather closed structure, to study in regards to long-term and
familiar associations. The present work looks at the
inter-relationship of nature versus nurture in regards to the
aetiology of Type 2 diabetes. A strong foetal and infant
nutritional role in the aetiology is noted allowing for the
proposal of targeted long-term lifestyle intervention programmes
which aim to influence the development of the disease starting from
intra-uterine life and maintained lifelong in individuals
identified as high risk.
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