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Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells - Novel Insights into Disease Mechanisms (Hardcover, 1st ed. 2016)
Loot Price: R5,422
Discovery Miles 54 220
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Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells - Novel Insights into Disease Mechanisms (Hardcover, 1st ed. 2016)
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Many breakthroughs in biological research and translational
healthcare advancements have been achieved by studying the response
of biological systems to extreme environments. The spaceflight
platform provides a unique environment where researchers can
explore fundamental questions into cellular and molecular response
mechanisms to unveil novel insight into human health and disease.
Since the physical force of gravity has shaped the architecture of
all biological systems on our planet, spaceflight provides the
opportunity to see life in a new adaptational mode - in response to
reduced gravity. This enables investigations into the effects of
the microgravity environment and associated changes in mechanical
forces on mammalian cells/tissues and microbial pathogens, to bring
novel insight into disease mechanisms, which are not discernable
using conventional experimental approaches. Research using
spaceflight platforms represents a paradigm shift in how we observe
life processes and is on the leading edge of research discoveries
into cellular and molecular mechanisms of health and disease. By
incorporating the views of leading authors, this book highlights
landmark discoveries and advances in mammalian cellular and
microbiology research in both true spaceflight and ground-based
spaceflight analogue environments for scientists and students alike
who are interested in the influence of physical forces on mammalian
and microbial cells, how this impacts transition between normal
homeostasis and disease, and basic mechanisms of adaptation to low
gravity environments. To provide a thorough understanding of this
research, this book covers a range of topics including: (i)
description the physical forces interacting with cells in
microgravity and microgravity analogue environments, (ii) how
alterations in these cellular forces impact human physiology,
specifically immune function, (iii) use of these environments to
develop organotypic three-dimensional (3-D) tissue culture models
as predictive human surrogates for organogenesis and disease
research, and (iv) microbial pathogen responses to culture in these
environments, focusing on infectious disease Collectively, this
information reflects a critical step in preparation for
long-duration human space exploration, advances our knowledge of
basic biological processes and mechanisms important to understand
normal function and disease, and may lead to new strategies for
treatment and prevention.
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