Since their discovery approximately 25 years ago, adenosine
receptors have now emerged as important novel molecular targets in
disease and drug discovery. These proteins play important roles in
the entire spectrum of disease from inflammation to immune
suppression. Because of their expression on a number of different
cell types and in a number of different organ systems they play
important roles in specific diseases, including asthma, rheumatoid
arthritis, Parkinson 's disease, multiple sclerosis, Alzheimer 's
disease, heart disease, stroke, cancer, sepsis, and obesity. As a
result of intense investigations into understanding the molecular
structures and pharmacology of these proteins, new molecules have
been synthesized that have high specificity for these proteins and
are now entering clinical trials. These molecules will define the
next new classes of drugs for a number of diseases with unmet
medical needs.
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