Van Etten, a pharmaceutical entrepreneur, tests drugs on bull sharks in hopes to extract their antibodies to cure human diseases. Before he can continue with his experiment, he tries to enlist Misty Calhoun, a shark conservationist, and other scientists to lead and endorse this project.
Soon though the drug-enhanced sharks quickly begin to adapt and learn new hunting skills. The humans lose control over the laboratory and now they have to fight to survive.
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