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Impact of Survivin Acetylation on its Biological Function (Paperback, 1st ed. 2017)
Loot Price: R1,790
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Impact of Survivin Acetylation on its Biological Function (Paperback, 1st ed. 2017)
Series: BestMasters
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In his research, David Dannheisig investigates the influence of
lysine129 acetylation on the biological function of survivin
including alteration of nucleocytoplasmic shuttling as well as
dimerization behavior. Since survivin participates in two major
hallmarks of oncogenesis, namely cell death inhibition and
chromosomal segregation during the cell cycle, it reflects a
valuable target in cancer therapy and research. The author
establishes proximity-dependent, fluorescence-microscopic methods
to quantify the interaction of survivin with the export receptor
Crm1 as well as the homodimerization itself. In the future, those
systems can be used to examine the feasible effect of chemical
modulators which are targeting these interactions in a cellular
background. The outcome achieved is an essential step towards the
enhancement of potential cancer therapies.
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