With the recent renaissance in mitochondrial biology and increasing
recognition of their role in many diseases, this book provides a
timely summary of the current state-of-the-art in mitochondrial
research. The book opens with the regulation of mitochondrial
replication and biogenesis and reviews the mechanisms and
functional consequences of mitochondrial fission and fusion.
Further chapters address mitochondria and oxidative stress and
their roles in cell signalling and cell death. The book includes
extensive, fascinating discussion of the biochemistry of
mitochondrial cell signalling (especially involving calcium) and of
oxidative stress. The nature of the proteins engaged in these
processes, many only recently discovered, is covered in detail.
Mitochondria have been strongly implicated in neurodegenerative
diseases such as Parkinson's, Huntington's and amyotrophic lateral
sclerosis. They are also affected in cancer, ageing and
cardiovascular disease. The final section of the book reviews
mitochondrial mutations and their consequences in ageing and other
phenotypic manifestations. The authors discuss how mitochondrial
proteins might constitute important therapeutic targets and
describe initial attempts to develop compounds that can regulate
their function.
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