Books > Medicine > Pre-clinical medicine: basic sciences > Physiology
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Molecular Signaling of Mammalian Inner Ear Development (Hardcover)
Loot Price: R4,116
Discovery Miles 41 160
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Molecular Signaling of Mammalian Inner Ear Development (Hardcover)
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The inner ear originates from an ectodermal thickening, the otic
placode, which lies adjacent to the developing hindbrain. Complex
interactions between regulatory signalling molecules guide
development of the simple otic placode into the elaborate,
multifunctional organs of hearing and balance. This book delves
into recent research in the field, focusing on successive stages of
inner ear development and how they are influenced by the
co-ordinate activity of signalling molecules. This book begins with
an overview of the evolutionary adaptation of the organ of Corti
(organ of hearing) and the molecular signals that characterise
ancestral development of the inner ear. Following this, the topics
addressed include the complex signalling interactions underlying
induction of the otic placode, key molecular mediators influencing
inner ear development and patterning, genetic signalling of the
vestibular (balance) system and clinical correlations to human
balance disorders, commitment to auditory hair cell fate, and
reliance of the inner ear on retinoic acid, a biologically-active
derivative of vitamin A, for appropriate development. This timely
and comprehensive book provides an excellent resource for
researchers, clinician-scientists and students alike.
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