Due to their importance to cell biology, DNA topology-altering
enzymes, collectively DNA topoisomerases and gyrases, have been
studied thoroughly from a biochemical perspective, yet the
expansion of research at the molecular and cellular levels
continues to show a great deal of promise. In DNA Topoisomerases:
Methods and Protocols, experts in the field present a compendium of
protocols that extends into the new areas of research that have
been recently uncovered in order to elucidate the methodology
needed to study topoisomerases in the molecular and cellular
context. The volume examines subjects such as the analysis of DNA
topologies and the interaction of topoisomerases with DNA as tools
to measure topoisomerase functions, the binding of topoisomerases
to specific sites in the genomes of eukaryotes, including origins
of DNA replication, as well as exploration of perturbed
topoisomerase function. As a volume in the highly successful
Methods in Molecular Biology(TM) series, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, laboratory protocols, and
notes on trouble-shooting and avoiding known pitfalls.
Cutting-edge and easy-to-use, DNA Topoisomerases: Methods and
Protocols provides key content which reflects an expanded
understanding of the functions of these essential enzymes in the
hope of inspiring researchers to further important discoveries in
this dynamic field.
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