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Molecular Immunotoxicology (Hardcover)
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Molecular Immunotoxicology (Hardcover)
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The human immune system is constantly exposed to chemical
contaminants, whether from food, water or air. Some chemicals
directly elicit an immune response, while others indirectly
activate or deactivate components within the immune system. Thus
when tracking or predicting the effect of a chemical on the immune
system, many different pathways and modes of action need to be
considered. Following an introduction to the various pathways and
toxicity mechanisms from a systemic perspective, the main part of
this comprehensive reference surveys individual molecular
mechanisms of important immunotoxicants, from PAHs to
biopharmaceuticals, and from receptor-mediated toxicity to
nanoparticle toxicity, using analyses based on molecular effects
rather than on animal models. Taken together, the knowledge
presented here provides an up-to-date overview of this hot topic
that can be directly applied to the prediction and characterization
of immunotoxic effects in drugs, chemicals, and environmental
contaminants.
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