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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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Rna Silencing (Hardcover)
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Rna Silencing (Hardcover)
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This book handles an emerging, central issue in molecular genetics
and the development of eukaryotes: the control of gene expression
by small species of RNA. As an exciting new field of endeavor, it
is the first book by a single author to deal comprehensively with
RNA silencing. The book provides the historical background of the
field preceding the seminal work by Fire and associates in 1998 on
the impact of small double-stranded RNA on the expression of
nematode genes, which is considered the beginning of RNA silencing
research, RNA silencing is described in a wide range of plants and
animals including protozoa, simple metazoa, insects, non-mammalian
vertebrates, and mammals. In each case the, experimental results
are provided with the accompanying background and with
illustrations. There is also an appendix on the prospective use of
RNA silencing in gene therapy, which is intended as a guide for
investigators wishing to explore this possibility.
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