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Experimental Models in Glioblastoma Research (Hardcover)
Loot Price: R3,769
Discovery Miles 37 690
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Experimental Models in Glioblastoma Research (Hardcover)
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This book covers the basic experimental models in glioblastoma
research. It starts with a description in the first two chapters of
general clinical, neuroimaging and genetic data about glioblastoma
(WHO grade IV glioma), which is the most frequent and the most
malignant primary tumour in adults. Despite the complex treatment
which includes neurosurgery, radiotherapy and chemotherapy,
survival of the patients usually is between 9 and 12 months.
Moreover, the surgery is not able to cure the disease due to the
specific infiltrative growth pattern of glioblastoma. Therefore,
laboratory research is essential in order to find new molecular and
cellular therapies for this lethal disease. After shortly reviewing
the modern hypothesis regarding the origin of glioblastoma in the
third chapter, namely the cancer stem cells hypothesis, the author
describes step-by-step in the following chapters (Chapters 4-8) the
most important in vitro and in vivo models of research in
glioblastoma. Chapter 4 is dedicated to the first and the essential
step in any research project on glioblastoma: how to obtain good
quality glioblastoma samples, how to prepare the samples and how to
store the samples long-term for subsequent research. Open surgery
and the image-guided stereotactic technique are also described in
this chapter. After obtaining the tumour samples, the next step is
to initiate the primary cells cultures. These in vitro techniques
(either serum conditioning cell cultures and tumour stem cells
cultures) will be discussed in detail in Chapters 5 and 6. Usually
the new molecules with antitumor activity are tested in vitro on
both primary glioblastoma cells cultures but also on glioblastoma
cells lines in order to obtain a better standardised results. The
next chapter, Chapter 7 is dedicated to in vivo techniques, which
are required for testing the anti-tumoural effect of the new
molecules before starting with the clinical trials. The author
describes in detail the techniques of stereotactic intracranial
inoculation of glioblastoma cells (either glioblastoma cell lines
or glioblastoma-derived tumour stem cells) and the main growth
patterns of the intracranial glioblastoma xenografts obtained using
these techniques. Another technique very useful for exploring in
real time the migratory glioblastoma cells is the organotypic brain
slice cultures which is described in the last chapter of the book.
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