Interleukin-10 (IL-10) is regarded as an immune suppressant
cytokine. This reputation is due to the experimental observation
that IL-10 decreases the function of antigen presenting cells and T
helper 1 type immune responses. Surprisingly, however, IL-10 has
potent anti-cancer effects since most experimental models
demonstrate immune-mediated anti-tumor effects whether IL-10 is
locally (tumor transfectant models) or systemically (transgenic
models, administration of soluble cytokine) provided. In addition,
recent work has suggested that polymorphisms of the promoter region
of IL-10 may segregate propulsions in high and low producers.
Surprisingly, high IL-10 producers may be more predisposed to
acquire cancer and other diseases. Finally, human observations
demonstrate that systemic administration of IL-10 to normal
volunteers is associated with very little toxicity and
pro-inflammatory properties mediated through activation of effector
cells of the innate immune response. Thus, the role that
interleukin-10 plays in vivo in physiological or pathological
conditions remains controversial. Thus, there exists a compelling
need to summarize in a book the state of the science of this
important cytokine. With the assistance of several experts in this
field, Interleukin-10 has attempted this endeavor.
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