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Optical Whispering Gallery Modes for Biosensing - From Physical Principles to Applications (Hardcover, 1st ed. 2020)
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Optical Whispering Gallery Modes for Biosensing - From Physical Principles to Applications (Hardcover, 1st ed. 2020)
Series: Biological and Medical Physics, Biomedical Engineering
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This interdisciplinary book covers the fundamentals of optical
whispering gallery mode (WGM) microcavities, light-matter
interaction, and biomolecular structure with a focus on
applications in biosensing. Novel biosensors based on the
hybridization of WGM microcavities and localized surface plasmon
resonances (LSPRs) in metal nanoparticles have emerged as the most
sensitive microsystem biodetection technology that boasts single
molecule detection capability without the need for amplification
and labeling of the analyte. The book provides an ample survey of
the physical mechanisms of WGMs and LSPRs for detecting affinity,
concentration, size, shape and orientation of biomarkers, while
informing the reader about different classes of biomolecules, their
optical properties and their importance in label-free clinical
diagnostics. For the more advanced reader, advanced applications of
WGMs and LSPRs in exploring the fundamental nature of quantum
physics are discussed.
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