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DNA Replication, Recombination, and Repair - Molecular Mechanisms and Pathology (Hardcover, 1st ed. 2016)
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DNA Replication, Recombination, and Repair - Molecular Mechanisms and Pathology (Hardcover, 1st ed. 2016)
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This book is a comprehensive review of the detailed molecular
mechanisms of and functional crosstalk among the replication,
recombination, and repair of DNA (collectively called the "3Rs")
and the related processes, with special consciousness of their
biological and clinical consequences. The 3Rs are fundamental
molecular mechanisms for organisms to maintain and sometimes
intentionally alter genetic information. DNA replication,
recombination, and repair, individually, have been important
subjects of molecular biology since its emergence, but we have
recently become aware that the 3Rs are actually much more
intimately related to one another than we used to realize.
Furthermore, the 3R research fields have been growing even more
interdisciplinary, with better understanding of molecular
mechanisms underlying other important processes, such as chromosome
structures and functions, cell cycle and checkpoints,
transcriptional and epigenetic regulation, and so on. This book
comprises 7 parts and 21 chapters: Part 1 (Chapters 1-3), DNA
Replication; Part 2 (Chapters 4-6), DNA Recombination; Part 3
(Chapters 7-9), DNA Repair; Part 4 (Chapters 10-13), Genome
Instability and Mutagenesis; Part 5 (Chapters 14-15), Chromosome
Dynamics and Functions; Part 6 (Chapters 16-18), Cell Cycle and
Checkpoints; Part 7 (Chapters 19-21), Interplay with Transcription
and Epigenetic Regulation. This volume should attract the great
interest of graduate students, postdoctoral fellows, and senior
scientists in broad research fields of basic molecular biology, not
only the core 3Rs, but also the various related fields (chromosome,
cell cycle, transcription, epigenetics, and similar areas).
Additionally, researchers in neurological sciences, developmental
biology, immunology, evolutionary biology, and many other fields
will find this book valuable.
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