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Biochemistry of the Mevalonic Acid Pathway to Terpenoids (Paperback, 1990 ed.)
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Biochemistry of the Mevalonic Acid Pathway to Terpenoids (Paperback, 1990 ed.)
Series: Recent Advances in Phytochemistry, 24
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This series of lectures was delivered at the 29th meeting of the
Phytochemical Society of North America, held at the University of
British Columbia in Vancouver, B. C. , Canada on June 16th-20th,
1989. Topics concerning terpenoids, consisting of isoprene units,
are now so numerous that a judicious selection for a relatively
limited symposium was difficult. We were able to assemble, however,
a potpourri of reviews on topical areas of terpenoid chemistry,
biochemistry and biology, by scientists who are making exciting
contributions and whose work points the way to significant future
research. Because of the importance of terpenoids in the life of
plants, and indeed in all living organisms, a periodical review of
the mevalonic acid pathway and of the subsequent biochemical events
leading to the biosynthesis of isoprenoids needs no justification.
Life, as we know it, would not be possible without the ability of
living organisms to employ this metabolic sequence which proceeds
from condensations of three molecules of acetyl-CoA and terminates
with the elaboration of the terpenoid precursors, isopentenyl
pyrophosphate and dimethylallyl pyrophosphate. In addition to
producing obviously essential compounds that are partially or
completely of isoprenoid origin (Fig. 1), such as hormones,
photosynthetic pigments, compounds involved in electron transport
in respiration and in photosynthesis, oxidative enzymes and
membrane components, plants elaborate thousands of novel
terpenoids, many of which do not as yet have identifiable
physiological, biochemical or even ecological roles, e. g. the
cardenolides, ecdysones or saponins.
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