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ADAMTS13 - Biology and Disease (Hardcover, 1st ed. 2015)
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ADAMTS13 - Biology and Disease (Hardcover, 1st ed. 2015)
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This comprehensive volume discusses the protease ADAMTS13,
summarizing the current status of basic and clinical research. The
nine authoritative chapters begin with a historical perspective
followed by exploration of the biochemistry and structure-function
relationships of ADAMTS13 as well as its normal function in
hemostasis (cleavage of von Willebrand factor). Emerging research
themes for ADAMTS13 are covered, including its potential role in
angiogenesis and other aspects of cell biology. Additional topics
include laboratory assays for ADAMTS13, inherited ADAMTS13
deficiency, and acquired ADAMTS13 deficiency. A chapter on related
thrombotic microangiopathic (TMA) disorders examines the
differences between TMAs associated with ADAMTS13 deficiency and
those not associated with ADAMTS13 deficiency. A final chapter
reviews the preliminary information on emerging aspects of
ADAMTS13, such as the status of recombinant ADAMTS13 products and
their potential utility. Comprehensive in its exploration of the
ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a
significant resource for clinical hematologists, transfusion
medicine physicians, and researchers interested in hemostasis,
vascular biology, biochemistry, and metalloproteases.
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