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Human Cytosolic Sulfotransferases (Hardcover)
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Human Cytosolic Sulfotransferases (Hardcover)
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The existence of multiple sulfotransferases (SULTS) was first
discovered in 1958. Since then, any attempts to create a
comprehensive text dedicated to sulfation and sulfotransferases
have been rare and, thanks to rapid advances in molecular biology
and biochemistry, quickly outdated. However, those advances have
permitted an accelerated understanding of human sulfotransferase
activity and with it the creation of a growing database on
sulfotransferases that, until now, has remained scattered in the
literature.
Human Cytosolic Sulfotransferases serves an important function by
the mere feat of culling the information from the literature to
present an up-to-date summary of the field. Fortunately, the
editors have gone a step further in providing us with a
multidisciplinary overview of human sulfotransferases, covering not
only basic biochemistry, genetics, and molecular biology, but also
exploring current clinical uses involving pharmacology, enzymology,
and environmental toxicology.
The book's thirteen chapters, written by some of the most renowned
scientists in the field, address the huge diversity of topics that
are impacted by sulfation. Included are discussions that move from
general nomenclature and structure to molecular cloning of human
cytosolic sulfotransferases, and sulfate conjugation in
pharmocogenetics and pharmacogenomics. Entire chapters focus on
sulfotransferases in the human fetus and neonate, sulfation of
thyroid hormones, as well as estrogen sulfotransferases in breast
cancer and the activation/inactivation of carcinogens and mutagens
by human sulfotransferases.
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