Some drugs which are not aimed at treating heart disease have
nevertheless been found to have profound effects on heart muscle.
Cardiotoxicity is one of the major forms of toxicity seen in drugs
and it accounts for most drug recalls and delays experienced in
regulatory approvals.In recent years a number of non-cardiac
blockbuster drugs such as terfenadine have been withdrawn from
major markets because of cardiotoxicity concerns, while other drugs
have either been withdrawn prior to marketing or required labelling
changes that significantly restricted their use. In Cardiotoxicity
of Non-Cardiovascular Drugs international experts describe the
molecular mechanisms and clinical read-outs of cardiac events
induced by a broad variety of noncardiovascular drugs. Particular
emphasis is paid to the preclinical screening of drug
cardiotoxicity. Topics include: * metabolic targets of
cardiotoxicity * regulatory aspects * translating molecular
mechanisms into clinical trials * structure-activity relationships
in arrhythmias by antihistamines and psychoactive drugs *
cardiovascular toxicity of antitumor drugs * cardiovascular
toxicities of non-steroidal anti-inflammatory drugs *
cardiovascular toxicities of antiretroviral therapies
Cardiotoxicity of Non-Cardiovascular Drugs is an essential guide to
this important area of drug development. It will find a place on
the bookshelves of researchers, regulators and students in
medicinal chemistry, drug development, pharmacology, pharmacy and
cardiovascular disease.
General
Imprint: |
John Wiley & Sons
|
Country of origin: |
United States |
Release date: |
April 2010 |
First published: |
June 2010 |
Authors: |
G Minotti
|
Dimensions: |
235 x 162 x 25mm (L x W x T) |
Format: |
Hardcover
|
Pages: |
360 |
Edition: |
New |
ISBN-13: |
978-0-470-77274-4 |
Categories: |
Books >
Medicine >
Clinical & internal medicine >
Cardiovascular medicine
|
LSN: |
0-470-77274-3 |
Barcode: |
9780470772744 |
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