The potential lipotoxic effect of accumulation of fatty acids in
non-adipose tissues is thought to be a major component in the
development of insulin resistance. Chronic exposure to high
concentrations of free fatty acids in the blood affects pancreatic
β cell function, insulin secretion and lipid synthesis in the
liver, and storage in adipose tissue. Maintaining the normal levels
of fatty acids requires coordinated regulation between the liver,
adipose tissue and skeletal muscle.
This book deals with the molecular aspects of fatty acid action
in obesity and insulin resistance. The topics include lipid
metabolism and adipose tissue biology, and β cell function and
insulin resistance. Chapters deal with the molecular genetics and
molecular physiology of energy homeostasis.
General
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