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Books > Earth & environment > The environment > Pollution & threats to the environment
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Environmentally Friendly Alkylphosphonate Herbicides (Hardcover, 2014 ed.)
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Environmentally Friendly Alkylphosphonate Herbicides (Hardcover, 2014 ed.)
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This book presents essential research on a class of environmentally
friendly alkylphosphonate herbicides. This class of herbicides
acted as a competitive inhibitor of the pyruvate dehydrogenase
complex (PDHc) to control weeds. The bioreasoning and systematic
approach, from basic research to field tests of candidate
compounds, are introduced. The basic research covers the molecular
design, chemical synthesis, biological activities evaluation,
structure-activity relationship analysis and structural
optimization. Subsequently, the book reviews the biochemistry of
PDHc inhibitors, the selectivity between mammals and plants, and
the mechanism of herbicidal activity of novel alkylphosphonates as
selective PDHc inhibitors. Field trials for selected
alkylphosphonate candidates as herbicides are also included. This
book provides a sound basis for the rational design and development
of novel herbicides as effective PDHc inhibitors with good
enzyme-selective inhibition of plant PDHc between mammals and
plants. These studies take full advantages of the low toxicity and
low residual impact of selective PHDc inhibitors to design an
effective and environmentally friendly herbicide. This book is
based on twenty years of research on alkylphosphonates and
phosphorus-containing PDHc inhibitors, and demonstrates how to
develop these PDHc inhibitors as an effective and "green" herbicide
candidate. Hong-Wu He, PhD, is a Professor at the Key Laboratory of
Pesticide & Chemical Biology, Ministry of Education of China,
and Director of the Institute of Pesticide Chemistry, College of
Chemistry, Central China Normal University, China. Hao Peng, PhD,
and Xiao-Song Tan are both Associate Professors at the Key
Laboratory of Pesticide & Chemical Biology, Ministry of
Education of China, College of Chemistry, Central China Normal
University, China.
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