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Diffuse Optical Tomography - Principles and Applications (Paperback)
Loot Price: R1,816
Discovery Miles 18 160
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Diffuse Optical Tomography - Principles and Applications (Paperback)
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Written by an authority involved in the field since its nascent
stages, Diffuse Optical Tomography: Principles and Applications is
a long-awaited profile of a revolutionary imaging method. Diffuse
Optical Tomography (DOT) provides spatial distributions of
intrinsic tissue optical properties or molecular contrast agents
through model-based reconstruction algorithms using NIR
measurements along or near the boundary of tissue. Despite the
practical value of DOT, many engineers from electrical or applied
mathematics backgrounds do not have a sufficient understanding of
its vast clinical applications and portability value, or its
uncommon advantages as a tool for obtaining functional, cellular,
and molecular parameters. A collection of the author's research and
experience, this book fuses historical perspective and experiential
anecdotes with fundamental principles and vital technical
information needed to successfully apply this
technology-particularly in medical imaging. This reference finally
outlines how to use DOT to create experimental image systems and
adapt the results of laboratory studies for use in clinical
applications including: Early-stage detection of breast tumors and
prostate cancer "Real-time" functional brain imaging Joint imaging
to treat progressive diseases such as arthritis Monitoring of tumor
response New contrast mechanisms and multimodality methods This
book covers almost every aspect of DOT-including reconstruction
algorithms based on nonlinear iterative Newton methods,
instrumentation and calibration methods in both continuous-wave and
frequency domains, and important issues of imaging contrast and
spatial resolution. It also addresses phantom experiments and the
development of various image-enhancing schemes, and it describes
reconstruction methods based on contrast agents and fluorescence
DOT. Offering a concise description of the particular problems
involved in optical tomography, this reference illustrates DOT's
fundamental foundations and the principle of image reconstruction.
It thoroughly explores computational methods, forward mathematical
models, and inverse strategies, clearly illustrating solutions to
key equations.
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