Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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Filaggrin - Basic Science, Epidemiology, Clinical Aspects and Management (Hardcover, 2014 ed.)
Loot Price: R2,991
Discovery Miles 29 910
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Filaggrin - Basic Science, Epidemiology, Clinical Aspects and Management (Hardcover, 2014 ed.)
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Filaggrin proteins are expressed in several human tissues,
including the skin, oral mucosa, conjunctivae, esophagus, cervix,
and testes. While filaggrin guarantees both structural and
functional normality of the human epidermis, its role in other
tissues is largely unknown. Epidermal deficiency of filaggrin
causes dry and scaly skin, but also strongly increases the risk of
skin diseases, in particular ichthyosis vulgaris and atopic
dermatitis. Importantly, the risk of related asthma, hay fever, and
food allergy is also increased although filaggrin is not expressed
in the airways and gastrointestinal tract. Common FLG mutations,
leading to reduced filaggrin expression, have mainly been
identified in Europeans and Asians, reaching a prevalence of 5-10%.
Even in the absence of atopic dermatitis, the skin of individuals
with FLG mutations differs fundamentally from normal skin, for
example by generating more vitamin D and allowing chemicals and
allergens to more widely penetrate across the stratum corneum. This
textbook provides comprehensive and detailed coverage of the
effects of filaggrin and filaggrin gene (FLG) mutations in health
and disease (cutaneous and non-cutaneous) and also discusses the
basic science, epidemiology, management, and future research areas.
It will be of value to scientists and clinicians from different
specialties.
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