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Growth Factors and Cytokines in Skeletal Muscle Development, Growth, Regeneration and Disease (Hardcover, 1st ed. 2016)
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Growth Factors and Cytokines in Skeletal Muscle Development, Growth, Regeneration and Disease (Hardcover, 1st ed. 2016)
Series: Advances in Experimental Medicine and Biology, 900
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This book describes the diverse roles that growth factors and
cytokines play in skeletal muscle. The extracellular environment
has profound effects on the biology of skeletal muscle. The soluble
portion of this environment includes a rich milieu of growth
factors and cytokines which have been shown to regulate virtually
all facets of the response of skeletal muscle to external stimuli,
whether it be exercise induced metabolic shifts, remodeling in
response to trauma or loading of the ongoing pathology associated
with neuromuscular disease. The chapters included in this work
illustrate growth factors that directly affect skeletal muscle
cells and those which influence non-muscle cells that contribute to
the biology of skeletal muscle as a whole tissue. The current state
of the art, with the advent of systems biology, allows for the
delineation of signaling networks which are regulated by suites of
growth factors. This is in stark contrast to early more traditional
studies, which only examined the effects of isolated growth factors
on the activity of skeletal muscle precursor cells in tissue
culture. The work presented in this volume ranges from reviewing
and analyzing the roles of individual growth factors in detail, to
the complex interplay of multiple soluble factors in the control of
muscle functional, and dysfunctional states. The material covered
in this volume will particularly suit readers from a range of
research fields spanning general muscle biology and physiology, and
those working on diseases and conditions affecting skeletal muscle
both directly and indirectly.
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