This textbook provides a fresh, comprehensive and accessible
introduction to the rapidly expanding field of molecular
pharmacology. Adopting a drug target-based, rather than the
traditional organ/system based, approach this innovative guide
reflects the current advances and research trend towards molecular
based drug design, derived from a detailed understanding of
chemical responses in the body. Drugs are then tailored to fit a
treatment profile, rather than the traditional method of 'trial and
error' drug discovery which focuses on testing chemicals on animals
or cell cultures and matching their effects to treatments.
Providing an invaluable resource for advanced under-graduate and
MSc/PhD students, new researchers to the field and practitioners
for continuing professional development, "Molecular Pharmacology
"explores; recent advances and developments in the four major human
drug target families (G-protein coupled receptors, ion channels,
nuclear receptors and transporters), cloning of drug targets,
transgenic animal technology, gene therapy, pharmacogenomics and
looks at the role of calcium in the cell. Current - focuses on
cutting edge techniques and approaches, including new methods to
quantify biological activities in different systems and ways to
interpret and understand pharmacological data.Cutting Edge -
highlights advances in pharmacogenomics and explores how an
individual's genetic makeup influences their response to
therapeutic drugs and the potential for harmful side
effects.Applied - includes numerous, real-world examples and a
detailed case-study based chapter which looks at current and
possible future treatment strategies for cystic fibrosis. This case
study considers the relative merits of both drug therapy for
specific classes of mutation and gene therapy to correct the
underlying defect.Accessible - contains a comprehensive glossary,
suggestions for further reading at the end of each chapter and an
associated website that provides a complete set of figures from
within the book.
A companion website with additional resources is available at
www.wiley.com/go/dickenson/dnamolecular
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