This is the first textbook of its kind devoted to describing the
biological complexities of breast cancer in a way that is relevant
to the radiation oncologist. Radiation Oncology has long treated
breast cancer as a single biological entity, with all treatment
decisions being based on clinical and pathologic risk factors. We
are now beginning to understand that biological subtypes of breast
cancer may have different risks of recurrence as well as different
intrinsic sensitivity to radiotherapy. Multi-gene arrays that have
for years been used to predict the risk of distant recurrence and
the value of systemic chemotherapy may also have utility in
predicting the risk of local recurrence. Additionally, the targeted
agents used to treat breast cancer may interact with radiotherapy
in ways that can be beneficial or undesirable. All of these
emerging issues are extensively discussed in this book, and
practical evidence-based treatment recommendations are presented
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