The Microbiome in Prenatal and Neonatal Life clarifies that the
microbiome in the maternal fetal unit and immediate changes that
occur as new microbes are acquired postnatally play major roles in
subsequent health and disease. Rapidly developing technologies for
multi-omic analyses and systems biology are shifting paradigms in
both scientific knowledge and clinical care with regard to this
topic. In essence, we are changing the idea that newborns emerge
from sterile environments. As such, in-utero colonization may have
impacts on the development of immunity and metabolism that, with
epigenetic modifications, will lead to diseases in later life. In
addition, the microbial profile that develops during and after
birth depends on mode of delivery, type of feeding (human milk
versus formula), and various other environmental factors to which
the newborn is exposed.
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