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Calcium Entry Pathways in Non-excitable Cells (Hardcover, 1st ed. 2016)
Loot Price: R5,707
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Calcium Entry Pathways in Non-excitable Cells (Hardcover, 1st ed. 2016)
Series: Advances in Experimental Medicine and Biology, 898
Expected to ship within 12 - 17 working days
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Calcium entry pathways in non-excitable cells presents a concise
synthesis of thoughtfully selected topics covering from the
different calcium entry mechanisms in non-excitable cells to the
cellular microdomains and organelles regulating the calcium entry
process. Particular attention is given to the fascinating group of
ion channels involved in different calcium entry pathways as well
as the emerging role of these channels in human disease. Calcium
entry is an essential mechanism for cellular function in
non-excitable cells. In general, two main calcium entry pathways
exist in non-excitable cells: one pathway, named store-operated
calcium entry (SOCE) requires store depletion and the second
pathway is regulated by receptor occupation, but independently on
calcium store depletion. The search for the molecular components of
calcium entry has identified the stromal interaction molecule 1
(STIM1), as the calcium sensor of the intracellular calcium stores,
and Orai as well as TRP channels as the calcium-permeable channels
located in the plasma membrane. The location, interactions and
function of these channels are finely regulated by a number of
scaffolding proteins, membrane microdomains and cellular organelles
that fine tune the amount of calcium entering the cell.
Cutting-edge and user-friendly, this volume presents relevant
background information, critical analysis of the current
observations and directions for future research. The book is
intended for basic scientists specializing in cellular biology or
ion transport, as well as for biomedical researchers.
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