Governments around the world are passing laws requiring industry to
assess the toxicity of the chemicals and products they produce, but
to do so while reducing, refining, or even replacing testing on
animals. To meet these requirements, experimental toxicologists and
risk assessors are adopting quantitative approaches and computer
simulations to study the biological fate and effects of chemicals
and drugs.
In "Quantitative Modeling in Toxicology" leading experts outline
the current state of knowledge on the modeling of dose, tissue
interactions and tissue responses. Each chapter describes the
mathematical foundation, parameter estimation, challenges and
perspectives for development, along with the presentation of a
modeling template. Additionally, tools and approaches for
conducting uncertainty, sensitivity and variability analyses in
these models are described. Topics covered include:
the quantitative models of pharmacokinetics of individual
chemicals and mixturesmodels for toxicant-target tissue
interaction. models for cellular, organ, and organism
responses.approaches, tools and challenges for model application
and evaluation
A website containing computer codes accompanies the book to help
the reader reconstruct the models described and discussed in the
various chapters.
"Quantitative Modeling in Toxicology" serves as an essential
reference source and tool box for risk assessors and researchers
and students in toxicology, public health, pharmacology, and human
toxicology interested in developing quantitative models for a
better understanding of dose-response relationships.
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